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US 2021/0285012 A1Published application
Method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
AssigneeThe Trustees of the University of Pennsylvania
InventorsGuangping Gao, James M. Wilson, Mauricio R. Alvira
Life of this patent
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Abstract
Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided.
Claims15
A recombinant adeno-associated virus (AAV) comprising an AAV capsid comprising vp1 proteins having the sequence of amino acids 1 to 738 of SEQ ID NO:
- 81, AAV vp2 proteins having the sequence of amino acids 138 to 738 of SEQ ID NO:
- 81, or AAV vp3 proteins having the sequence of amino acids 204 to 738 of SEQ ID NO:
- 81, wherein said vp1 proteins have up to 7 amino acid substitutions, and wherein the recombinant AAV further comprises, packaged within the capsid, a nucleic acid molecule comprising at least one AAV inverted terminal repeat (ITR), and a non-AAV nucleic acid sequence encoding a gene product operably linked to sequences which direct expression of the product in a host cell.
A recombinant adeno-associated virus (AAV) comprising an AAV capsid comprising vp1 proteins having the sequence of amino acids 1 to 738 of SEQ ID NO:
- 81, AAV vp2 proteins having the sequence of amino acids 138 to 738 of SEQ ID NO:
- 81, or AAV vp3 proteins having the sequence of amino acids 204 to 738 of SEQ ID NO:
- 81, wherein said vp2 proteins have up to 7 amino acid substitutions, and wherein the recombinant AAV further comprises, packaged within the capsid, a nucleic acid molecule comprising at least one AAV inverted terminal repeat (ITR), and a non-AAV nucleic acid sequence encoding a gene product operably linked to sequences which direct expression of the product in a host cell.
A recombinant adeno-associated virus (AAV) comprising an AAV capsid comprising vp1 proteins having the sequence of amino acids 1 to 738 of SEQ ID NO:
- 81, AAV vp2 proteins having the sequence of amino acids 138 to 738 of SEQ ID NO:
- 81, or AAV vp3 proteins having the sequence of amino acids 204 to 738 of SEQ ID NO:
- 81, wherein said vp3 proteins have up to 7 amino acid substitutions, and wherein the recombinant AAV further comprises, packaged within the capsid, a nucleic acid molecule comprising at least one AAV inverted terminal repeat (ITR), and a non-AAV nucleic acid sequence encoding a gene product operably linked to sequences which direct expression of the product in a host cell.
Dependencies are inferred from the claim text.