# US 2021/0280279 A1 · Generating medical analysis using a joint model based on multivariate ordinal data

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- Number: US 2021/0280279 A1
- Document ID: US20210280279A1
- Status: Published application
- Kind: A1
- Application number: 17/194,188
- Filed: 2021-03-05
- Published: 2021-09-09
- Earliest claimed: 2020-03-05
- Applicants: Otsuka America Pharmaceutical, Inc.
- Inventors: Srikanth Gottipati; Guoqing Diao; Peter Zhang
- Web page: https://patentgrep.com/patent/US20210280279A1

## CPC

- G16H 10/20: for electronic clinical trials or questionnaires
- G16H 40/67: for remote operation
- G16H 20/10: relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H 20/70: relating to mental therapies, e.g. psychological therapy or autogenous training
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- G16H 50/30: for calculating health indices; for individual health risk assessment
- G16H 70/40: relating to drugs, e.g. their side effects or intended usage
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

Methods, systems, and apparatuses, including computer programs for analyzing multi-variate ordinal outcomes. In one aspect, the method can include actions of obtaining one or more answers to one or more questions of a first assessment, generating a first group of processing data based on the one or more answers, wherein the first group of processing data comprises one or more ordinal values, one or more covariates, and one or more factors, generating output data based on the first group of processing data, generating a medical analysis corresponding to the one or more answers provided by a first user based on the output data and one or more other outputs from one or more other generated groups of processing data, and sending the medical analysis to a first device.

## Claims

### Claim 1

A computer-implemented method for analyzing multi-variate ordinal outcomes, the method comprising:
obtaining, by one or more computers, one or more answers to one or more questions of a first assessment;
generating, by the one or more computers, a first group of processing data based on the one or more answers, wherein the first group of processing data comprises one or more ordinal values, one or more covariates, and one or more factors;
generating, by the one or more computers, output data based on the first group of processing data;
generating, by the one or more computers, a medical analysis corresponding to the one or more answers provided by a first user based on the output data and one or more other outputs from one or more other generated groups of processing data; and
sending, by the one or more computers, the medical analysis to a first device.

### Claim 2 (depends on 1)

The computer-implemented method of claim 1, further comprising:
receiving, by the one or more computers, a processing request from a second device;
responsive to receiving the processing request from the second device, obtaining, by the one or more computers, the first assessment, wherein the first assessment comprises the one or more questions, wherein the first assessment is stored within an assessment database of one or more assessments, and wherein the assessment database is communicably connected to the one or more computers; and
sending, by the one or more computers, the first assessment to the second device, wherein the second device enables the first user to provide the one or more answers to the one or more questions of the first assessment.

### Claim 3 (depends on 1)

The computer-implemented method of claim 1, wherein generating the first group of processing data comprises:
extracting, by the one or more computers, the one or more ordinal values from the one or more answers;
identifying, by the one or more computers, the one or more covariates from the one or more answers; and
generating, by the one or more computers, the one or more factors based on the one or more answers.

### Claim 4 (depends on 1)

The computer-implemented method of claim 1, wherein the one or more factors comprise one or more of negative symptoms, positive symptoms, disorganized thought, uncontrolled hostility or excitement, or anxiety or depression.

### Claim 5 (depends on 1)

The computer-implemented method of claim 1, wherein the one or more covariates comprise one or more of treatment group, age, or gender.

### Claim 6 (depends on 1)

The computer-implemented method of claim 1, wherein the medical analysis comprises a determined effect of a drug treatment, wherein the first user is engaged in the drug treatment.

### Claim 7

A system for analyzing multi-variate ordinal outcomes, the system comprising:
one or more computers; and
one or more memories storing instructions that, when executed by the one or more computers, cause the one or more computers to perform operations, the operations comprising:
obtaining, by the one or more computers, one or more answers to one or more questions of a first assessment;
generating, by the one or more computers, a first group of processing data based on the one or more answers, wherein the first group of processing data comprises one or more ordinal values, one or more covariates, and one or more factors;
generating, by the one or more computers, output data based on the first group of processing data;
generating, by the one or more computers, a medical analysis corresponding to the one or more answers provided by a first user based on the output data and one or more other outputs from one or more other generated groups of processing data; and
sending, by the one or more computers, the medical analysis to a first device.

### Claim 8 (depends on 7)

The system of claim 7, the operations further comprising:
receiving, by the one or more computers, a processing request from a second device;
responsive to receiving the processing request from the second device, obtaining, by the one or more computers, the first assessment, wherein the first assessment comprises the one or more questions, wherein the first assessment is stored within an assessment database of one or more assessments, and wherein the assessment database is communicably connected to the one or more computers; and
sending, by the one or more computers, the first assessment to the second device, wherein the second device enables the first user to provide the one or more answers to the one or more questions of the first assessment.

### Claim 9 (depends on 7)

The system of claim 7, wherein generating the first group of processing data comprises:
extracting, by the one or more computers, the one or more ordinal values from the one or more answers;
identifying, by the one or more computers, the one or more covariates from the one or more answers; and
generating, by the one or more computers, the one or more factors based on the one or more answers.

### Claim 10 (depends on 7)

The system of claim 7, wherein the one or more factors comprise one or more of negative symptoms, positive symptoms, disorganized thought, uncontrolled hostility or excitement, or anxiety or depression.

### Claim 11 (depends on 7)

The system of claim 7, wherein the one or more covariates comprise one or more of treatment group, age, or gender.

### Claim 12 (depends on 7)

The system of claim 7, wherein the medical analysis comprises a determined effect of a drug treatment, wherein the first user is engaged in the drug treatment.

### Claim 13

A computer-readable storage medium storing instructions that, when executed by one or more computers, cause the one or more computers to perform operations, the operations comprising:
obtaining one or more answers to one or more questions of a first assessment;
generating a first group of processing data based on the one or more answers, wherein the first group of processing data comprises one or more ordinal values, one or more covariates, and one or more factors;
generating output data based on the first group of processing data;
generating a medical analysis corresponding to the one or more answers provided by a first user based on the output data and one or more other outputs from one or more other generated groups of processing data; and
sending the medical analysis to a first device.

### Claim 14 (depends on 13)

The computer-readable storage medium of claim 13, the operations further comprising:
receiving a processing request from a second device;
responsive to receiving the processing request from the second device, obtaining the first assessment, wherein the first assessment comprises the one or more questions, wherein the first assessment is stored within an assessment database of one or more assessments, and wherein the assessment database is communicably connected to the one or more computers; and
sending the first assessment to the second device, wherein the second device enables the first user to provide the one or more answers to the one or more questions of the first assessment.

### Claim 15 (depends on 13)

The computer-readable storage medium of claim 13, wherein generating the first group of processing data comprises:
extracting, by the one or more computers, the one or more ordinal values from the one or more answers;
identifying, by the one or more computers, the one or more covariates from the one or more answers; and
generating, by the one or more computers, the one or more factors based on the one or more answers.

### Claim 16 (depends on 13)

The computer-readable storage medium of claim 13, wherein the one or more factors comprise one or more of negative symptoms, positive symptoms, disorganized thought, uncontrolled hostility or excitement, or anxiety or depression.

### Claim 17 (depends on 13)

The computer-readable storage medium of claim 13, wherein the one or more covariates comprise one or more of treatment group, age, or gender.

### Claim 18 (depends on 13)

The computer-readable storage medium of claim 13, wherein the medical analysis comprises a determined effect of a drug treatment, wherein the first user is engaged in the drug treatment.
