# US 2021/0278340 A1 · Analyte detector with nano-antennas

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- Number: US 2021/0278340 A1
- Document ID: US20210278340A1
- Status: Published application
- Kind: A1
- Application number: 17/255,823
- Filed: 2019-06-27
- Published: 2021-09-09
- Earliest claimed: 2018-07-06
- Assignees: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
- Applicants: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
- Inventors: Beniamino SCIACCA; Arjen BOERSMA
- Web page: https://patentgrep.com/patent/US20210278340A1

## CPC

- G01N 21/3504: for analysing gases, e.g. multi-gas analysis
- G01N 21/21: Polarisation-affecting properties (G01N21/19 takes precedence)
- G01N 21/554: {detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance}
- G01N 21/658: {enhancement Raman, e.g. surface plasmons}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A device for the detection of analytes comprises a substrate (10) with nano-antennas (11,12). The nano-antennas (11,12) comprise an antenna material (11m, 12m) for forming resonant antenna structures which receive and resonantly interact with source light (L0) to form respective resonance peaks (R1,R2) over a resonant wavelength range (A1,A2) overlapping respective signature wavelength of a target analyte (A). The resonant interaction causes a locally concentrated field (Ec) of the source light (L0) in the resonant wavelength range (A1,A2). The concentrated intensity (Ic) is localized around a respective target location (T1,T2) which is provided with a sorption material (11s, 12s) that sorbs the target analyte (A). This provides a locally increased analyte concentration (Ac) of the target analyte (A) coinciding with the locally concentrated field (Ec) of the source light (L0). Accordingly, the interaction of the source light (L0) with the target analyte (A) is enhanced.

## Claims

### Claim 1

An analyte detector comprising:
at least one substrate with a plurality of nano-antennas configured to receive a target analyte with a spectral signature having absorption peaks at different signature wavelengths,
a light source configured to provide a source light having a source intensity over a source wavelength range including different source light wavelengths for interaction with the target analyte at the different signature wavelengths according to the spectral signature; and
a light sensor for detecting a spectrum of the different source light wavelengths of the light having interacted with the target analyte at the different signature wavelengths for determining the spectral signature of the target analyte;
wherein the nano-antennas comprise an antenna material forming resonant antenna structures configured to receive and resonantly interact with the source light to form a respective resonance peak over a resonant wavelength range overlapping a respective signature wavelength of the target analyte,
wherein the resonant interaction with the source light causes a locally concentrated field of the source light in the resonant wavelength range,
wherein the locally concentrated field is localized around a respective target location of the nano-antennas and/or substrate;
wherein the target location is provided with a sorption material for sorbing the target analyte to provide a locally increased analyte concentration of the target analyte coinciding with the locally concentrated field of the source light for enhancing the interaction of the source light with the target analyte;
wherein different nano-antennas with the same sorption material in their respective target locations are configured to provide respective resonance peaks in different resonant wavelength ranges to overlap the different signature wavelengths of the spectral signature; and
wherein the light travels along a light path from the light source to the light sensor with the nano-antennas there between, wherein the light path is configured to allow the light from the light source to interact with at least two different nano-antennas before arriving at the light sensor.

### Claim 2 (depends on 1)

The analyte detector according to claim 1, wherein at least part of the light path is formed by one or more optical wave guides configured to guide the light along one or more different nano-antennas.

### Claim 3 (depends on 1)

The analyte detector according to claim 1, wherein light is guided through one or more tapered optical wave guides, wherein the different nano-antennas are disposed at different locations along the waveguides.

### Claim 4 (depends on 1)

The analyte detector according to claim 1, wherein the light path is configured to reflect multiple times between substrates to have the light consecutively interact with at least two different ones of the nano-antennas.

### Claim 5 (depends on 1)

The analyte detector according to claim 1, wherein the light path is configured to transmit through multiple substrates to have the light interact with at least two different ones of the nano-antennas.

### Claim 6 (depends on 1)

The analyte detector according to claim 1, wherein the nano-antennas comprise at least one nano-antenna configured to resonantly interact with the source light to provide:
a first resonance for a first polarization direction of the source light covering a first wavelength range overlapping a first signature wavelength of the target analyte; and
a second resonance, for a second polarization direction of the source light, differing from the first polarization direction, covering a second wavelength range overlapping a second signature wavelength of the target analyte, different from the first signature wavelength.

### Claim 7 (depends on 1)

The analyte detector according to claim 1, further comprising a heater to increase the temperature of the sorption material for desorbing part of the one or more analytes from sorption material.

### Claim 8 (depends on 1)

The analyte detector according to claim 1 further comprising a cooler to decrease the temperature of the sorption material for increasing the sorption of the one or more analytes in sorption material.

### Claim 9 (depends on 1)

The analyte detector according to claim 1, wherein the different nano-antennas differ from each other by a characteristic size or shape, such as a length or diameter of the nano-antennas, wherein the different characteristic sizes provide the different resonance peaks in different resonant wavelength ranges, wherein the characteristic sizes differ between the said different nano-antennas by at least a factor 1.01.

### Claim 10 (depends on 1)

The analyte detector according to claim 1, wherein the respective resonance peaks of different ones of the nano-antennas have peak intensities at different wavelengths, wherein the wavelengths differ by at least a factor 1.01.

### Claim 11 (depends on 1)

The analyte detector according to claim 1, wherein at least some of the resonance peaks of different ones of the nano-antennas cover exclusive wavelength ranges, wherein a full width half maximum of a first resonance peak has no overlap with a full width half maximum of a second resonance peak.

### Claim 12 (depends on 1)

The analyte detector according to claim 1, wherein at least some of the resonance peaks of different nano-antennas cover partially overlapping wavelength ranges, wherein a full width half maximum of a first resonance peak partially overlaps between 5-95% of a full width half maximum of a second resonance peak.

### Claim 13

A method of detecting analytes, the method comprising
providing at least one substrate with a plurality of nano-antennas;
exposing the at least one substrate with nano-antennas to a target analyte with a spectral signature having absorption peaks at signature wavelengths,
exposing the nano-antennas to a source light with a source intensity over a source wavelength range including the signature wavelengths for interaction with the target analyte according to the spectral signature, wherein the nano-antennas comprise an antenna material for forming resonant antenna structures that receive and resonantly interact with the source light to form a respective resonance peak over a resonant wavelength range overlapping a respective signature wavelength of the target analyte, wherein the resonant interaction causes a locally concentrated field of the source light in the resonant wavelength range, wherein, the concentrated field is localized around a respective target location of the nano-antennas and/or substrate;
wherein the target location is provided with a sorption material that sorbs the target analyte to provide a locally increased analyte concentration of the target analyte coinciding with the locally concentrated field of the source light thereby enhancing the interaction of the source light with the target analyte;
wherein different ones of the nano-antennas with the same sorption material in their respective target locations provide respective resonance peaks in different resonant wavelength ranges to overlap different signature wavelengths of the spectral signature.

### Claim 14 (depends on 13)

The method according to claim 13, wherein at least one substrate with a plurality of the nano-antennas is provided by a process comprising
solution phase synthesis of the plurality of nano-antennas; and
deposition of formed nano-antennas on the at least one substrate
wherein the deposition comprises using a template with slots for determining a position and/or direction of the nano-antennas on the substrate.

### Claim 15 (depends on 13)

The method according to claim 13, further comprising:
exposing the nano-antennas to a first beam of source light having a first polarization, wherein the nano-antennas are oriented to exclusively or predominantly absorb source light having the first polarization;
exposing the nano-antennas to second beam of source light having a second polarization, perpendicular to the first polarization; and
measuring respective resulting signals of the first and second beams of light source light interacting with the nano-antennas, wherein the signals resulting from the second beams of light source are used as reference.