# US 2021/0278326 A1 · Systems and methods for extracting analytes from a sample

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- Number: US 2021/0278326 A1
- Document ID: US20210278326A1
- Status: Published application
- Kind: A1
- Application number: 17/240,442
- Filed: 2021-04-26
- Published: 2021-09-09
- Earliest claimed: 2019-04-29
- Assignees: ANKOM Technology Corporation
- Applicants: ANKOM Technology Corporation
- Inventors: Andrew R. Komarek; Richard Giannetti; Michael Drew Komarek; Ronald J. Komarek; Ryan J. Komarek; Steven T. Lauffer; Marleen van Aardt
- Web page: https://patentgrep.com/patent/US20210278326A1

## CPC

- G01N 1/38: Diluting, dispersing or mixing samples
- B01B 1/005: {Evaporation for physical or chemical purposes; Evaporation apparatus therefor, e.g. evaporation of liquids for gas phase reactions}
- B01D 11/0434: {comprising rotating mechanisms, e.g. mixers, rotational oscillating motion, mixing pumps}
- B01J 20/14: Diatomaceous earth
- G01N 1/4022: {by thermal techniques; Phase changes}
- G01N 1/405: {by adsorption or absorption}
- G01N 1/4077: {by other techniques involving separation of suspended solids}
- B01J 2219/00495: Means for heating or cooling the reaction vessels
- G01N 2001/386: {Other diluting or mixing processes}
- G01N 2001/4027: {evaporation leaving a concentrated sample}
- G01N 2001/4088: {filtration}
- G01N 2035/00534: {Mixing by a special element, e.g. stirrer}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- B01B: BOILING; BOILING APPARATUS {; EVAPORATION; EVAPORATION APPARATUS}
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS

## Abstract

Systems and methods for extracting an analyte from a sample. The system includes a reaction vessel for receiving the sample and a reaction solution, a mixer for mixing the sample with the reaction solution, a filter and a drain for passing soluble components from the reaction mixture, including the dissolved analyte, from the reaction vessel. A purification vessel is located below the reaction vessel. A selective sorbent is disposed in the purification vessel for retaining contaminants from the soluble components from the reaction mixture and passing a purified analyte. An evaporation container is located below the purification vessel. A heater heats the evaporation chamber and evaporates the solvents from the purified analyte, which can then be quantitatively measured.

## Claims

### Claim 1

A system for extracting an analyte from a sample, the system comprising:
a reaction chamber comprising:
a reaction vessel configured to receive and mix the sample with a reaction solution to produce a reaction mixture,
a filter configured to retain insoluble components contained within the reaction mixture while passing soluble components of the reaction mixture, and
a reaction vessel drain configured to dispense the soluble components from the reaction mixture and a dissolved analyte from the reaction vessel;
a purification chamber comprising:
a purification vessel column configured to receive the soluble components from the reaction mixture and the dissolved analyte, from the reaction vessel drain,
a selective sorbent disposed in the purification vessel configured to retain contaminants from the soluble components of the reaction mixture and passing a purified analyte, and
a purification vessel drain for dispensing the purified analyte from the purification vessel;
an evaporation chamber comprising:
an evaporation vessel configured to receive the purified analyte from the purification vessel drain; and
a heater configured to evaporate a solvent from the purified analyte.

### Claim 2 (depends on 1)

The system of claim 1, wherein the reaction vessel, the purification vessel, and the evaporation vessel are vertically aligned along an axis.

### Claim 3 (depends on 1)

The system of claim 1, wherein the reaction vessel further comprises a mixer comprising a stir bar and a magnetic driver configured to create a magnetic flux field for driving the stir bar about an axis.

### Claim 4 (depends on 1)

The system of claim 1, wherein the purification vessel further comprises a diffuser for diffusing the soluble components from the reaction mixture, including the dissolved analyte, received from the reaction vessel.

### Claim 5 (depends on 1)

The system of claim 1, wherein the purification vessel further comprises a selective sorbent composed from a solid phase filter material.

### Claim 6 (depends on 1)

The system of claim 1, further comprising a blower for blowing a heated gas into one of the evaporation and reaction chambers.

### Claim 7 (depends on 5)

The system of claim 5, wherein the solid phase filter material is selected from the group consisting of siliceous earth or diatomaceous earth.

### Claim 8

A system for extracting an analyte from a sample, the system comprising:
a reaction chamber comprising a reaction vessel configured to receive the sample with a reaction solution, separate insoluble components from a reaction mixture and dispense soluble components, including a dissolved analyte, from the reaction mixture,
a purification chamber comprising a purification vessel configured to receive the soluble components, including the dissolved analyte, from the reaction vessel, separate contaminants from the soluble components and dispense a purified analyte from the purification vessel; and
an evaporation chamber comprising an evaporation vessel configured to receive the purified analyte from the purification vessel.

### Claim 9 (depends on 8)

The system of claim 8, further comprising:
a heater configured to evaporate a solvent from the purified analyte.

### Claim 10 (depends on 9)

The system of claim 9, wherein the reaction vessel, the purification vessel, and the evaporation vessel are vertically aligned along an axis.

### Claim 11 (depends on 9)

The system of claim 9, wherein the reaction vessel further comprises a mixer comprising a stir bar and a magnetic driver configured to create a magnetic flux field for driving the stir bar about an axis.

### Claim 12 (depends on 9)

The system of claim 9, wherein the reaction vessel is detachable.

### Claim 13 (depends on 9)

The system of claim 9, wherein the purification vessel is detachable.

### Claim 14 (depends on 9)

The system of claim 9, wherein the purification vessel further comprises a selective sorbent composed from a solid phase filter material.

### Claim 15 (depends on 14)

The system of claim 14, wherein the solid phase filter material is selected from the group consisting of siliceous earth or diatomaceous earth.

### Claim 16 (depends on 9)

The system of claim 9, further comprising a blower for blowing a heated gas into one of the evaporation and reaction chambers.

### Claim 17

A method for extracting an analyte from a sample, the method comprising the steps of:
mixing the sample with a reaction solution in a reaction vessel to produce a reaction mixture,
separating insoluble components from the reaction mixture;
dispensing soluble components, including a dissolved analyte, from the reaction mixture,
receiving the soluble components, including the dissolved analyte, into a purification vessel;
separating contaminants from the soluble components; and
dispensing a purified analyte of the soluble component from the purification vessel into an evaporation vessel.

### Claim 18 (depends on 17)

The method of claim 17 further comprising the step of:
heating the purified analyte to evaporate a solvent from the evaporation vessel.

### Claim 19 (depends on 17)

The method of claim 17 further comprising the step of:
aligning the reaction, purification and evaporation vessels along an axis to allow gravity assisted flow from one vessel to another vessel.

### Claim 20 (depends on 17)

The method of claim 17 further comprising the step of:
blowing a heated gas into one of the reaction, purification and evaporation