Aav variants with enhanced tropism
AssigneesVoyager Therapeutics, Inc., California Institute of Technology
InventorsDinah Wen-Yee Sah, Jinzhao Hou, Kei Adachi, Wei Wang, Qingmin Chen, Jenna Carroll Soper, Amy Ren, Xiao-Qin Ren, Benjamin E. Deverman, Viviana Gradinaru, Qin Huang
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Abstract
The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
Claims24
An AAV capsid protein comprising (i) a parent VP1 amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 or SEQ ID NO:
- 3, and (ii) at least one targeting peptide inserted into the parent VP1 amino acid sequence of (i), wherein the targeting peptide is selected from any member of the group consisting of SEQ ID NO:
- 4-14326 and any member of the group consisting of SEQ ID NO:
- 42973-42999.
A peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 4-14326 and SEQ ID NO:
- 42973-42999.
Dependencies are inferred from the claim text.