# US 2021/0277328 A1 · Musk compositions and methods of use thereof

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- Number: US 2021/0277328 A1
- Document ID: US20210277328A1
- Status: Published application
- Kind: A1
- Application number: 17/209,056
- Filed: 2021-03-22
- Published: 2021-09-09
- Earliest claimed: 2015-06-29
- Assignees: Takasago International Corporation
- Applicants: Takasago International Corporation
- Inventors: Raphael K. L. Kang; Alba T. Cilia
- Web page: https://patentgrep.com/patent/US20210277328A1

## CPC

- C11B 9/0084: {the hetero rings containing more than six atoms}
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/35: Ketones, e.g. benzophenone
- A61K 8/37: Esters of carboxylic acids
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/12: Ketones
- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/215: of carboxylic acids
- A61K 31/23: of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K 31/365: Lactones
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/22: Anxiolytics
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 5/02: Preparations for cleaning the hair
- A61Q 13/00: Formulations or additives for perfume preparations (essential oils or perfumes per se C11B9/00)
- A61Q 15/00: Anti-perspirants or body deodorants (deodorisation of air A61L9/00)
- C11B 9/0015: {containing oxygen as the only heteroatom}
- C11B 9/0019: {carbocylic acids; Salts or esters thereof}
- C11B 9/0034: {the ring containing six carbon atoms}
- C11B 9/0061: {compounds containing a six-membered aromatic ring not condensed with another ring}
- C11B: PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES (drying-oils C09F)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A fragrance composition comprising one or more musk or fragrance accords for use in reducing or inhibiting a subject's physiological reaction to stress. The composition can be incorporated into consumer products.

## Claims

### Claim 1

A method of reducing or inhibiting a stress response in a subject in need thereof, comprising administering a fragrance composition in an amount effective to reduce or inhibit a stress response to stress stimuli, wherein the fragrance comprises:
a) at least one musk accord; and
b) one or more bases, solvents and combinations thereof, and
wherein the at least one musk accord comprises at least one musk compound selected from the group consisting of 1,4-dioxacycloheptadecane-5,17-dione, (12E)-1-oxacyclohexadec-12-en-2-one, 5-cyclohexadecen-1-one, 3-methyl-5-((1R)-2,2,3-trimethylcyclopentyl)pentan-2-one, 1,4-dioxacyclohexadecane-5,16-dione, 16-oxacyclohexadecan-1-one, 11-oxa-16-hexadecanolide, (1R,6S)-ethyl 2,2,6-trimethylcyclohexanecarboxylate, 1-(3,3-dimethylcyclohexyl)ethyl acetate, and combinations thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the musk accord comprises (12E)-1-oxacyclohexadec-12-en-2-one.

### Claim 3 (depends on 1)

The method of claim 1, wherein at least one musk accord comprises:
i) a first musk compound 1,4-dioxacycloheptadecane-5,17-dione;
ii) a second musk compound selected from the group consisting of (12E)-1-oxacyclohexadec-12-en-2-one, 5-cyclohexadecen-1-one and 3-methyl-5-((1R)-2,2,3-trimethylcyclopentyl)pentan-2-one; and
iii) a third musk compound selected from the group consisting of 1,4-dioxacyclohexadecane-5,16-dione, 16-oxacyclohexadecan-1-one, 11-oxa-16-hexadecanolide, (1R,6S)-ethyl 2,2,6-trimethylcyclohexanecarboxylate, and 1-(3,3-dimethylcyclohexyl)ethyl acetate.

### Claim 4 (depends on 1)

The method of claim 1, wherein the at least one musk accord comprises 1,4-dioxacycloheptadecane-5,17-dione, (12E)-1-oxacyclohexadec-12-en-2-one, 1,4-dioxacyclohexadecane-5,16-dione, 16-oxacyclohexadecan-1-one, and 11-oxa-16-hexadecanolide.

### Claim 5 (depends on 1)

The method of claim 1, wherein the at least one musk accord comprises (1R,6S)-ethyl 2,2,6-trimethylcyclohexanecarboxylate, 5-cyclohexadecen-1-one, and 1,4-dioxacycloheptadecane-5,17-dione.

### Claim 6 (depends on 1)

The method of claim 1, wherein the at least one musk accord comprises a fragrance compound selected from the group consisting of raspberry ketone, linalool linalyl acetate, and combinations thereof.

### Claim 7 (depends on 1)

The method of claim 1, wherein the at least one musk accord is present in the fragrance composition in an amount of from about 1% to about 100% by the weight of fragrance composition.

### Claim 8 (depends on 1)

The method of claim 1, wherein the at least one musk accord is present in the fragrance composition in an amount of at least about 5%.

### Claim 9 (depends on 1)

The method of claim 1, wherein the at least one musk accord is present in the fragrance composition in an amount of at least about 10%.

### Claim 10 (depends on 1)

The method of claim 1, wherein the at least one musk accord is present in the fragrance composition in an amount of at least about 20%.

### Claim 11 (depends on 1)

The method of claim 1, wherein the fragrance composition can be administered to the subject before, during or after exposure to the stress stimuli.

### Claim 12 (depends on 1)

The method of claim 1, wherein the stress response is change in at least one hormone in the subject.

### Claim 13 (depends on 12)

The method of claim 12, wherein the at least one hormone is selected from the group consisting of cortisol, alpha amylase, and combinations thereof.