# US 2021/0277325 A1 · Process for producing microemulsion system of nano essential oil

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- Number: US 2021/0277325 A1
- Document ID: US20210277325A1
- Status: Published application
- Kind: A1
- Application number: 16/835,940
- Filed: 2020-03-31
- Published: 2021-09-09
- Earliest claimed: 2020-03-06
- Assignees: Wakamono Joint Stock Company
- Applicants: Wakamono joint stock company
- Inventors: Hong Ngoc Thi Dang; Nam Hai Lai
- Web page: https://patentgrep.com/patent/US20210277325A1

## CPC

- C11B 9/00: Essential oils; Perfumes
- A61K 8/068: {Microemulsions}
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/553: {Phospholipids, e.g. lecithin}
- A61K 8/922: {of vegetable origin}
- A61K 9/1075: {Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence)}
- A61Q 19/00: Preparations for care of the skin
- A61K 2800/10: General cosmetic use
- C11B: PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES (drying-oils C09F)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention relates to the process for producing an microemulsion system of nano essential oil, the process comprising the following steps: (i) preparing a dispersed phase of essential oil; (ii) preparing of a carrier formed from a mixture of diethylene glycol monoethyl ether and lecithin; (iii) adding the carrier to the dispersed phase while keeping the dispersed phase temperature between 60 and 100° C. after addition of the carrier, while simultaneously stirring under vacuum; then pass the entire solution mixture through the system of high-pressure homogeneous machine integrated dispersion nozzle; (iv) adding the solution mixture obtained in step (iii) to Capryol 90 while keeping the mixture temperature between 60 and 100° C., and stirring at a rate ranging from 400 up to 800 rpm under vacuum; (v) cooling the mixture, homogenizing the mixture by ultrasonication to achieve a droplet size smaller than 100 n.

## Claims

### Claim 1

A process for producing a microemulsion system of nano essential oil comprising the following steps:
(i) preparing a dispersed phase by heating an essential oil to a temperature between 60 and 100° C.;
(ii) preparing a carrier by heating a mixture of diethylene glycol monoethyl ether and lecithin at the weight ratio of between 5:1.5 and 6:1 to a temperature ranging from 60 to 100° C. under vacuum by using a rotary vacuum evaporator system, followed by cooling the mixture to 30° C., then respectively ultrasonicating for 30 minutes, magnetic stirring, and heating at temperature from 60 to 100° C. within 30 minutes, collecting the solution ang introducing into the rotary vacuum evaporator system, and continuing to stir at 100° C.;
(iii) adding the carrier to the dispersed phase at the weight ratio of between 2:1.5 and 2:1 while keeping the dispersed phase temperature between 60 and 100° C. after addition the carrier, while simultaneously stirring at a rate ranging from 400 and 800 rpm under vacuum; then passing the entire solution mixture through a system of a high-pressure homogeneous machine integrated with a dispersion nozzle;
(iv) adding the solution mixture obtained in step (iii) to Capryol 90 (propylene glycol monocaprylate) at the weight ratio of between 4:1.5 and 4.5:1 while keeping the mixture temperature between 60 and 100° C. after the addition of Capryol 90, then stirring at a rate ranging from 400 to 800 rpm under vacuum;
(v) preparing microemulsion system of nano essential oil by cooling the mixture to 25° C., homogenizing the mixture by ultrasonication using an ultrasonic homogenizer over a period from 30 to 60 minutes to achieve the a droplet size smaller than 100 nm, controlling the quality of the resultant product by dissolution in water and measurement of the transparency, in which if the required transparency is not met, continue to heat and measure the transparency every 30 minutes until the required transparency is met, stopping the reaction, and performing emulsifying on the solution mixture in an emulsifying device at a stirring rate ranging from 400 to 800 rpm to obtain the microemulsion system of nano essential oil.

### Claim 2 (depends on 1)

The process according to claim 1, in which in step (ii), the weight ratio of diethylene glycol monoethyl ether and lecithin is 5:1.

### Claim 3 (depends on 1)

The process according to claim 1, in which in step (iii), the weight ratio of the carrier and the dispersed phase is 2:1.

### Claim 4 (depends on 1)

The process according to claim 1, in which in step (iv), the weight ratio of the solution mixture obtained in step (iii) and Capryol 90 (propylene glycol monocaprylate) is 4:1.