# US 2021/0275939 A1 · Marsdenia cundurango creeper extracts, cosmetic compositions comprising them and cosmetic uses of same

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2021/0275939 A1
- Document ID: US20210275939A1
- Status: Published application
- Kind: A1
- Application number: 16/484,784
- Filed: 2018-02-06
- Published: 2021-09-09
- Earliest claimed: 2017-02-09
- Assignees: ISP Investments Inc.; Jafer Enterprises R&D, S.L. (Sociedad Unipersonal)
- Applicants: ISP Investments LLC; Jafer Enterprises R&D, S.L. (Sociedad Unipersonal)
- Inventors: Anne CLAY; Nouha DOMLOGE; Isabelle IMBERT; Karine CUCUMEL; Esmeralda CICCHETTI; Ludivine MUR; GARNIER Sébastien; Leslie DUROURE
- Web page: https://patentgrep.com/patent/US20210275939A1

## CPC

- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- B01D 11/0203: {with a supercritical fluid}
- A61K 8/63: Steroids; Derivatives thereof
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 36/27: Asclepiadaceae (Milkweed family), e.g. hoya
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/08: Anti-ageing preparations
- A61Q 19/10: Washing or bathing preparations
- B01D 11/0288: {Applications, solvents}
- A61K 2800/805: Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
- Y02P 20/54: using solvents, e.g. supercritical solvents or ionic liquids
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

## Abstract

The invention relates to a method for obtaining a Marsdenia cundurango extract containing terpinyl cinnamate compounds, the Marsdenia cundurango bark or wood extracts comprising terpinyl cinnamate compounds obtained by the method, cosmetic compositions comprising them, and the cosmetic uses of same for improving the barrier function of the skin, for improving protection against toxins and detoxification of the skin, and finally for reducing the signs of ageing.

## Claims

### Claim 1

A method for obtaining a Marsdenia cundurango extract comprising terpinyl cinnamate compounds, characterised in that the method comprises the following steps:
a) the bark and/or wood of Marsdenia cundurango creepers are/is collected, dried and then milled;
b) an extraction is performed with a fluid in the supercritical state,
c) the Marsdenia cundurango extract is recovered,
d) the extract obtained in step c) possibly is purified.

### Claim 2 (depends on 1)

The method according to claim 1, characterised in that the fluid in the supercritical state is carbon dioxide.

### Claim 3 (depends on 1)

The method according to claim 1, characterised in that the extraction of step b) is performed at a temperature between 45 and 55° C. and at a pressure between 200 and 260 bar within the extractor.

### Claim 4 (depends on 1)

The method according to claim 1, characterised in that the Marsdenia cundurango extract contains at least 10% by weight of terpinyl cinnamate compounds.

### Claim 5 (depends on 1)

The method according to any one of claim 1, characterised in that in step b) at least one apolar co-solvent is also used.

### Claim 6 (depends on 5)

The method according to claim 5, characterised in that the apolar co-solvent is an agro-sourced solvent selected from vegetable oils, acid esters and long- or short-chain alcohols, such as ethyl acetate, ethyl lactate, ethyl propionate, isopropyl palmitate, ethyl oleate, methyl stearate, oleyl oleate, triethyl citrate, glycerol caprylate/caprate triglyceride, or agro-sourced C10 to C14 hydrocarbons, or a combination of these solvents.

### Claim 7 (depends on 1)

A Marsdenia cundurango creeper bark and/or wood extract obtained by the method according to claim 1, characterised in that it is pasty and comprises terpinyl cinnamate compounds in a concentration of at least 10% by weight of the total weight of the extract.

### Claim 8 (depends on 5)

A Marsdenia cundurango creeper bark and/or wood extract obtained by the method according to claim 5, characterised in that the extract is in liquid form and comprises terpinyl cinnamate compounds in a concentration of from 0.5% to 2% by weight of the total weight of the extract.

### Claim 9 (depends on 7)

The Marsdenia cundurango extract according to claim 7, characterised in that the terpinyl cinnamate compounds are of following general formula I:
in which:
the radicals R1, R2, R3, R4, R5, R6 and R7 represent protons, methyls or saturated or non-saturated oxidised or non-oxidised alkyl chains,
the radicals R8, R9, R10 and R11 represent protons, methyls, or oxidised or non-oxidised, saturated or non-saturated, cyclic or non-cyclic alkyl groups,
the dotted lines illustrate the potential presence of an unsaturated bond at this position.

### Claim 10 (depends on 9)

The extract of claim 9, characterised in that the terpinyl cinnamate compounds are in particular β-amyrin cinnamate, 24-methylene cycloartanyl cinnamate, butyrospermyl cinnamate, cycloartenyl cinnamate and cyclofontumienyl cinnamate.

### Claim 11 (depends on 8)

The extract according to claim 8, characterised in that the extract originates from Marsdenia cundurango creeper bark.

### Claim 12 (depends on 8)

A cosmetic composition, characterised in that it comprises, by way of active agent, an effective amount of a Marsdenia cundurango extract according to claim 8 and a physiologically acceptable excipient.

### Claim 13 (depends on 12)

The composition according to claim 12, characterised in that the Marsdenia cundurango extract is present in the composition at a concentration of from 0.01 to 10% by weight in relation to the total weight of the composition, preferably from 0.01 to 5%.

### Claim 14 (depends on 12)

The composition according to claim 12, characterised in that it is formulated for topical application to the skin.

### Claim 15 (depends on 12)

Cosmetic use of a composition according to claim 12 for improving the barrier function of the skin, for improving protection against toxins, for increasing the detoxification capabilities of the skin, and for reducing the signs of ageing.

### Claim 16 (depends on 12)

A cosmetic treatment method for increasing the expression of bitter taste receptors in the skin cells, comprising the topical application of a composition according to claim 12.