# US 2021/0275835 A1 · Device for inducing exfoliation of cells and/or tissue fragments for enhanced cytopathologic cell collection

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- Number: US 2021/0275835 A1
- Document ID: US20210275835A1
- Status: Published application
- Kind: A1
- Application number: 17/007,953
- Filed: 2020-08-31
- Published: 2021-09-09
- Earliest claimed: 2019-08-29
- Assignees: Adenocyte Ltd.
- Applicants: Adenocyte Ltd.
- Inventors: Dan Adam
- Web page: https://patentgrep.com/patent/US20210275835A1

## CPC

- A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092})
- A61B 8/481: {involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream}
- A61N 2007/0004: {Applications of ultrasound therapy}
- A61N 2007/0039: {using microbubbles}
- A61N 2007/0073: {using multiple frequencies}
- A61N 2007/0078: {with multiple treatment transducers}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

An ultrasound probe configured for insonating a pancreas. The probe is sized and shaped to be placed on a patient's abdomen in an area that is just between the right and left rib cage sections. The probe transmits ultrasound energy in order to insonate substantially the entire pancreas at the same time. One or more cavitation detectors are positioned within the probe to detect an incidence of cavitation.

## Claims

### Claim 1

An ultrasound probe, comprising:
a housing comprising a front wall, a rear wall, a right wall, a left wall and a segment that is sized and shaped to fit in an external area of a patient between a right rib cage section and a left rib cage section;
a plurality of piezoelectric elements disposed within the housing; and
a plurality of cavitation detectors disposed within the housing.

### Claim 2 (depends on 1)

The ultrasound probe of claim 1, whereby the plurality of piezoelectric elements are each configured to emit ultrasound energy of the same frequency.

### Claim 3 (depends on 2)

The ultrasound probe of claim 2, whereby the same frequency is a frequency in a range between 2 MHz-4 MHz.

### Claim 4 (depends on 1)

The ultrasound probe of claim 1, whereby respective one of the plurality of piezoelectric elements are configured to emit ultrasound energy of different frequencies.

### Claim 5 (depends on 1)

The ultrasound probe of claim 1 further comprising a control unit electrically coupled to the ultrasound probe.

### Claim 6 (depends on 5)

The ultrasound probe of claim 5, whereby the control unit is configured to control functions of the ultrasound probe.

### Claim 7 (depends on 6)

The ultrasound probe of claim 6, whereby the functions comprise and of duration of emission of ultrasound energy, intensity of ultrasound energy, frequency of transmitted waveforms and length of ultrasound energy bursts.

### Claim 8 (depends on 7)

The ultrasound probe of claim 7, whereby the control unit is configured to receive signals from respective ones of the plurality of cavitation detectors and run a remediation routine in response.

### Claim 9 (depends on 8)

The ultrasound probe of claim 8, whereby the remediation routine comprises reducing an intensity of ultrasound energy emitted from one or more of the plurality of piezoelectric elements disposed.

### Claim 10 (depends on 9)

The ultrasound probe of claim 9, whereby the remediation routine comprises reducing an intensity of ultrasound energy emitted to an area where cavitation was detected.