# US 2021/0275812 A1 · High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0275812 A1 - Document ID: US20210275812A1 - Status: Published application - Kind: A1 - Application number: 17/330,310 - Filed: 2021-05-25 - Published: 2021-09-09 - Earliest claimed: 2017-01-19 - Assignees: Nevro Corporation - Applicants: Nevro Corp. - Inventors: Jeyakumar Subbaroyan; Kerry Bradley; Dongchul Lee - Web page: https://patentgrep.com/patent/US20210275812A1 ## CPC - A61N 1/36062: {Spinal stimulation} - A61N 1/36171: {Frequency} - A61N 1/0551: {Spinal or peripheral nerve electrodes} - A61N 1/36139: {with automatic adjustment} - A61N 1/36157: {Current (A61N1/3616 takes precedence)} - A61N 1/36175: {Pulse width or duty cycle} - A61N 1/37217: {characterised by the communication link, e.g. acoustic or tactile} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods. A representative method includes addressing the patient's somatosensory dysfunction and/or motor dysfunction, resulting from neuropathy and/or spinal cord injury, by directing an electrical therapy signal to the patient's spinal cord region, the therapy signal having a frequency in a frequency range from 1.5 kHz to 100 kHz. ## Claims ### Claim 1 A method of treating a patient having sensation loss, via spinal cord stimulation, comprising: programming a signal generator to deliver a non-paresthesia producing electrical signal to the patient's spinal cord via at least one implanted signal delivery element, wherein the non-paresthesia producing electrical signal at least partially restores sensation that was lost, and wherein the sensation was lost in association with diabetic neuropathy. ### Claim 2 (depends on 1) The method of claim 1 wherein the signal generator is implantable, the at least one implanted signal delivery element is positioned in the patient's thoracic vertebral region between T8 and T12, and the non-paresthesia producing electrical signal has (a) a pulse width in a pulse width range of 10 microseconds to 333 microseconds, and (b) an amplitude in an amplitude range of 0.5 milliamps to 10 milliamps. ### Claim 3 (depends on 1) The method of claim 1 wherein the non-paresthesia producing electrical signal has a frequency in a frequency range of 1.5 kHz to 100 kHz. ### Claim 4 (depends on 1) The method of claim 1 wherein the non-paresthesia producing electrical signal has a frequency in a frequency range of 5 kHz to 25 kHz. ### Claim 5 (depends on 1) The method of claim 1 wherein the non-paresthesia producing electrical signal has a frequency of 10 kHz. ### Claim 6 (depends on 1) The method of claim 1 wherein the non-paresthesia producing electrical signal has a pulse width in a pulse width range of 10 microseconds to 333 microseconds. ### Claim 7 (depends on 1) The method of claim 1 wherein the non-paresthesia producing electrical signal has a pulse width in a pulse width range of 25 microseconds to 35 microseconds. ### Claim 8 (depends on 1) The method of claim 1 wherein the non-paresthesia producing electrical signal has an amplitude in an amplitude range of 0.5 milliamps to 10 milliamps. ### Claim 9 (depends on 1) The method of claim 1 wherein the at least one implanted signal delivery element is positioned in the patient's thoracic vertebral region. ### Claim 10 (depends on 9) The method of claim 9 wherein the at least one implanted signal delivery element is positioned in the patient's thoracic vertebral region between T8 and T12, inclusive. ### Claim 11 (depends on 1) The method of claim 1 wherein the at least one implanted signal delivery element is positioned in the patient's epidural space. ### Claim 12 (depends on 1) The method of claim 1 wherein the sensation loss is in the patient's foot or leg, and wherein the non-paresthesia producing electrical signal at least partially restores the sensation that was lost in the patient's foot or leg. ### Claim 13 (depends on 1) The method of claim 1 wherein the non-paresthesia producing electrical signal at least partially alleviates extremity pain associated with the diabetic neuropathy in addition to restoring the sensation. ### Claim 14 (depends on 1) The method of claim 1 wherein programming the signal generator includes programming the signal generator in response to the patient having sensation loss associated with the diabetic neuropathy. ### Claim 15 (depends on 1) The method of claim 1 wherein the sensation lost in association with the diabetic neuropathy includes sensation loss caused by diabetes. ### Claim 16 A method of treating a patient having a loss of sensation, via spinal cord stimulation, comprising: programming a signal generator to deliver, via at least one implanted signal delivery element, a non-paresthesia producing electrical signal to the patient's spinal cord to at least partially restore sensation that was lost in association with diabetic neuropathy. ### Claim 17 (depends on 16) The method of claim 16 wherein the signal generator is implantable, the at least one implanted signal delivery element is positioned in the patient's thoracic vertebral region between T8 and T12, and the non-paresthesia producing electrical signal has (a) a pulse width in a pulse width range of 10 microseconds to 333 microseconds, and (b) an amplitude in an amplitude range of 0.5 milliamps to 10 milliamps. ### Claim 18 (depends on 16) The method of claim 16 wherein the non-paresthesia producing electrical signal has a frequency in a frequency range of 1.5 kHz to 100 kHz. ### Claim 19 (depends on 16) The method of claim 16 wherein the non-paresthesia producing electrical signal has a frequency of 10 kHz. ### Claim 20 (depends on 16) The method of claim 16 wherein the non-paresthesia producing electrical signal has (a) a pulse width in a pulse width range of 10 microseconds to 333 microseconds, and (b) an amplitude in an amplitude range of 0.5 milliamps to 10 milliamps. ### Claim 21 (depends on 16) The method of claim 16 wherein the non-paresthesia producing electrical signal has (a) a pulse width in a pulse width range of 25 microseconds to 35 microseconds, and (b) an amplitude in an amplitude range of 0.5 milliamps to 10 milliamps. ### Claim 22 (depends on 16) The method of claim 16 wherein the at least one implanted signal delivery element is positioned in the patient's thoracic vertebral region between T8 and T12, inclusive. ### Claim 23 (depends on 16) The method of claim 16 wherein the non-paresthesia producing electrical signal at least partially eliminates sensations of tingling, pins-and-needles, and/or electric shock associated with the diabetic neuropathy. ### Claim 24 (depends on 16) The method of claim 16 wherein the sensation loss is in the patient's foot or leg, and wherein the non-paresthesia producing electrical signal at least partially restores the sensation that was lost in the patient's foot or leg. ### Claim 25 (depends on 16) The method of claim 16 wherein the non-paresthesia producing electrical signal at least partially alleviates extremity pain associated with the diabetic neuropathy in addition to restoring the sensation. ### Claim 26 (depends on 16) The method of claim 16 wherein programming the signal generator includes programming the signal generator in response to the patient having sensation loss associated with the diabetic neuropathy. ### Claim 27 (depends on 16) The method of claim 16 wherein the sensation lost in association with the diabetic neuropathy includes sensation loss caused by diabetes. ### Claim 28 A method of treating a patient having sensation loss, via spinal cord stimulation, comprising: directing an electrical signal to the patient's spinal cord region via an implanted signal delivery element, wherein the electrical signal at least partially restores sensation that was lost in association with diabetic neuropathy without causing paresthesia in the patient. ### Claim 29 (depends on 28) The method of claim 28 wherein the electrical signal has (a) a frequency in a frequency range of 1.5 kHz to 100 kHz, (b) a pulse width in a pulse width range of 10 microseconds to 333 microseconds, and (c) an amplitude in an amplitude range of 0.5 milliamps to 10 milliamps. ### Claim 30 (depends on 28) The method of claim 28 wherein the electrical signal at least partially alleviates sensations of tingling, pins-and-needles, and/or electric shock associated with the diabetic neuropathy in addition to restoring the sensation.