# US 2021/0275784 A1 · Method of treatment for various diseases > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0275784 A1 - Document ID: US20210275784A1 - Status: Published application - Kind: A1 - Application number: 17/329,765 - Filed: 2021-05-25 - Published: 2021-09-09 - Earliest claimed: 2012-11-02 - Assignees: Neurotronic, Inc. - Applicants: Neurotronic, Inc. - Inventors: Lixiao Wang - Web page: https://patentgrep.com/patent/US20210275784A1 ## CPC - A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) - A61M 25/1002: {characterised by balloon shape (A61M25/1006, A61M25/1009 take precedence)} - A61B 18/06: caused by chemical reaction {, e.g. moxaburners} - A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)} - A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates - A61M 5/007: {for contrast media} - A61M 5/142: Pressure infusion, e.g. using pumps - A61M 5/172: electrical or electronic - A61M 25/1011: {Multiple balloon catheters} - A61M 29/02: Dilators made of swellable material {(balloon catheters for angioplasty A61M25/104)} - A61N 7/022: {intracavitary} - A61B 2018/00285: {Balloons} - A61B 2018/00494: {Stomach, intestines or bowel} - A61B 2018/00511: {Kidney} - A61B 2018/00541: {Lung or bronchi} - A61B 2018/00577: {Ablation} - A61B 2018/0212: {using an instrument inserted into a body lumen, e.g. catheter} - A61B 2018/044: {the surgical action being effected by a circulating hot fluid} - A61B 2018/046: {in liquid form} - A61B 2018/048: {in gaseous form} - A61M 2025/105: {having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes} - A61M 2025/1052: {for temporarily occluding a vessel for isolating a sector} - A61M 2202/02: Gases - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, nonalcoholic fatty liver disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms. ## Claims ### Claim 1 A method for treating a body lumen, the method comprising: inserting a first delivery catheter into a first treatment site in a splenic artery, a hepatic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery; infusing a chemical formulation and/or delivering energy from the first delivery catheter to a tissue of the body lumen at the first treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the first treatment site; withdrawing the first delivery catheter from the first treatment site; inserting a second delivery catheter that is the same or different as the first delivery catheter into a second treatment site in a splenic artery, a hepatic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery, wherein the second treatment site is a different treatment site than the first treatment site; infusing a chemical formulation and/or delivering energy from the second delivery catheter to a tissue of the body lumen at the second treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the second treatment site; and withdrawing the second delivery catheter from the second treatment site; wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reduction of body weight, reduction of HbA1c (A1c) and/or glucose level, reducing blood pressure, or a combination thereof. ### Claim 2 (depends on 1) The method of claim 1, wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reduction of body weight. ### Claim 3 (depends on 1) The method of claim 1, wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reduction of HbA1c (A1c) and/or glucose level. ### Claim 4 (depends on 1) The method of claim 1, wherein the injury and/or damage to the tissue at the first treatment site and to the tissue at the second treatment site is effective to have a benefit of reducing blood pressure. ### Claim 5 (depends on 1) The method of claim 1, wherein the method further comprises: inserting a third delivery catheter that is the same or different as the first or second delivery catheter into a third treatment site in a splenic artery, a hepatic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery, wherein the third treatment site is a different treatment site than the first and second treatment site; infusing a chemical formulation and/or delivering energy from the third delivery catheter to a tissue of the body lumen at the third treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the third treatment site; and withdrawing the third delivery catheter from the third treatment site; wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reduction of body weight, reduction of HbA1c (A1c) and/or glucose level, reducing blood pressure, or a combination thereof. ### Claim 6 (depends on 5) The method of claim 5, wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reduction of body weight. ### Claim 7 (depends on 5) The method of claim 5, wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reduction of HbA1c (A1c) and/or glucose level. ### Claim 8 (depends on 5) The method of claim 5, wherein the injury and/or damage to the tissue at the first, second, and third treatment sites is effective to have a benefit of reducing blood pressure. ### Claim 9 (depends on 5) The method of claim 5, further comprising: inserting a fourth delivery catheter that is the same or different as the first, second, or third delivery catheter into a fourth treatment site in a splenic artery, a hepatic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery, wherein the fourth treatment site is a different treatment site than the first, second, and third treatment sites; infusing a chemical formulation and/or delivering energy from the fourth delivery catheter to a tissue of the body lumen at the fourth treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the fourth treatment site; and withdrawing the fourth delivery catheter from the fourth treatment site; wherein the injury and/or damage to the tissue at the first, second, third, and fourth treatment sites is effective to have a benefit of reduction of body weight, reduction of HbA1c (A1c) and/or glucose level, reducing blood pressure, or a combination thereof. ### Claim 10 (depends on 9) The method of claim 9, wherein the injury and/or damage to the tissue at the first, second, third, and fourth treatment sites is effective to have a benefit of reduction of body weight. ### Claim 11 (depends on 9) The method of claim 9, wherein the injury and/or damage to the tissue at the first, second, third, and fourth treatment sites is effective to have a benefit of reduction of HbA1c (A1c) and/or glucose level. ### Claim 12 (depends on 9) The method of claim 9, wherein the injury and/or damage to the tissue at the first, second, third, and fourth treatment sites is effective to have a benefit of reducing blood pressure. ### Claim 13 (depends on 1) The method of claim 1, wherein the first and/or second delivery catheter is a balloon catheter and the method further comprises: inflating the first delivery catheter after the insertion to the first treatment site and deflating the first delivery catheter prior to the withdrawing from the first treatment site; and/or inflating the second delivery catheter after the insertion to the second treatment site and deflating the second delivery catheter prior to the withdrawing from the second treatment site. ### Claim 14 (depends on 1) The method of claim 1, wherein the method comprises infusing the chemical formulation from the first and/or second delivery catheter to the tissue of the body lumen at the first and/or second treatment site. ### Claim 15 (depends on 14) The method of claim 14, wherein the chemical formulation comprises ethanol, acetic acid, ethanol and water, an ethanol/water azeotrope, or ethanol and acetic acid. ### Claim 16 (depends on 14) The method of claim 14, wherein the chemical formulation comprises ethanol. ### Claim 17 (depends on 1) The method of claim 1, wherein the method comprises delivering energy from the first and/or second delivery catheter to the tissue of the body lumen at the first and/or second treatment site. ### Claim 18 (depends on 17) The method of claim 17, wherein the energy is chosen from radiofrequency, cryoablation, microwave, laser, ultrasound, high intensity focused ultrasound, and combinations thereof. ### Claim 19 (depends on 17) The method of claim 17, wherein the energy comprises radiofrequency energy. ### Claim 20 (depends on 17) The method of claim 17, wherein the energy comprises ultrasound energy. ### Claim 21 (depends on 17) The method of claim 17, wherein the energy comprises vapor condensation of at least some of the chemical formulation to a liquid. ### Claim 22 (depends on 1) The method of claim 1, wherein the first and/or second delivery catheter comprises a needle catheter or a needle-based catheter. ### Claim 23 (depends on 1) The method of claim 1, further comprising flushing the first and/or second treatment sites with saline or water. ### Claim 24 (depends on 1) The method of claim 1, further comprising flushing the first and/or second delivery catheter with saline or water. ### Claim 25 A method for treating a body lumen, the method comprising: inserting a first delivery catheter into a first treatment site in a splenic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, a renal artery, a main renal artery, a main renal branch artery, an extra-renal artery, or an extra-renal branch artery; infusing a chemical formulation and/or delivering energy from the first delivery catheter to a tissue of the body lumen at the first treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the first treatment site; withdrawing the first delivery catheter from the first treatment site; inserting a second delivery catheter that is the same or different as the first delivery catheter into a second treatment site in a splenic artery, a common hepatic artery, a hepatic celiac artery, a left hepatic artery, a right hepatic artery, a proper hepatic artery, wherein the second treatment site is a different treatment site than the first treatment site; infusing a chemical formulation and/or delivering energy from the second delivery catheter to a tissue of the body lumen at the second treatment site, wherein the chemical formulation infused and/or the energy delivered is effective to injure and/or damage the tissue at the second treatment site; and withdrawing the second delivery catheter from the second treatment site. ### Claim 26 (depends on 25) The method of claim 25, wherein the energy is chosen from radiofrequency, cryoablation, microwave, laser, ultrasound, high intensity focused ultrasound, and combinations thereof. ### Claim 27 (depends on 25) The method of claim 25, wherein the energy comprises radiofrequency energy. ### Claim 28 (depends on 25) The method of claim 25, wherein the first and/or second delivery catheter is a balloon catheter and the method further comprises: inflating the first delivery catheter after the insertion to the first treatment site and deflating the first delivery catheter prior to the withdrawing from the first treatment site; and/or inflating the second delivery catheter after the insertion to the second treatment site and deflating the second delivery catheter prior to the withdrawing from the second treatment site. ### Claim 29 (depends on 25) The method of claim 25, wherein the method comprises infusing the chemical formulation from the first and/or second delivery catheter to the tissue of the body lumen at the first and/or second treatment site. ### Claim 30 (depends on 29) The method of claim 29, wherein the chemical formulation comprises ethanol, acetic acid, ethanol and water, an ethanol/water azeotrope, or ethanol and acetic acid. ### Claim 31 (depends on 29) The method of claim 29, wherein the chemical formulation comprises ethanol. ### Claim 32 (depends on 31) The method of claim 31, wherein the first and/or second delivery catheter comprises a needle catheter or a needle-based catheter. ### Claim 33 (depends on 25) The method of claim 25, wherein the first and/or second delivery catheter comprises a needle catheter or a needle-based catheter. ### Claim 34 (depends on 25) The method of claim 25, further comprising flushing the first and/or second treatment sites with saline or water. ### Claim 35 (depends on 25) The method of claim 25, further comprising flushing the first and/or second delivery catheter with saline or water. ### Claim 36 (depends on 33) The method of claim 33, wherein the needle-based balloon delivery catheter comprises: a proximal end; a distal end; a wire lumen; a formulation infusion lumen and/or a vacuum lumen; and a flushing port. ### Claim 37 (depends on 29) The method of claim 29, wherein the formulation is delivered into the body lumen wall.