Solution comprising fluorescent dye as fiducial marker
AssigneesDanmarks Tekniske Universitet, Nanovi A/S
InventorsJonas Rosager HENRIKSEN, Thomas Lars ANDRESEN, Anders Elias HANSEN, Andreas Tue Ingemann JENSEN, Linda Maria BRUUN, Rasmus Irming JØLCK
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Abstract
The present disclosure relates to a solution comprising a water insoluble carbohydrate and a fluorescent dye, such as a near infrared (NIR) contrast agent, wherein the solution sets under aqueous conditions, such as in vivo, to form e.g. a gel, a glass, a semi-solid, a solid, a crystal or any mixtures thereof. The disclosure further relates to preparation of such solution and use of such solution for in vivo imaging and/or guidance of surgery or interventional therapeutic procedures.
Claims31
A solution comprising
- a. a water insoluble carbohydrate,
- b. a fluorescent dye, and
- c. an organic solvent having a log P in the range of −2 to 2.
A method of in vivo imaging, the method comprising
- a. administering a solution according to any one of the preceding claims to an individual in need thereof,
- b. excitation of the fluorescent dye, and
- c. detection of the fluorescent dye.
Dependencies are inferred from the claim text.