# US 2021/0275593 A1 · Method of treating a bacterial infection using colostrum

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- Number: US 2021/0275593 A1
- Document ID: US20210275593A1
- Status: Published application
- Kind: A1
- Application number: 17/159,932
- Filed: 2021-01-27
- Published: 2021-09-09
- Earliest claimed: 2020-03-05
- Assignees: King Saud University
- Applicants: King Saud University
- Inventors: Khawla Ibrahim Alsamhary; Nagwa Mohamed Mohamed Amin Aref; Adel Almogren
- Web page: https://patentgrep.com/patent/US20210275593A1

## CPC

- A61K 35/20: Milk; Whey; Colostrum
- A61K 9/10: Dispersions; Emulsions
- A61K 9/19: lyophilised {, i.e. freeze-dried, solutions or dispersions (lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00)}
- A61P 31/04: Antibacterial agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The method of treating a bacterial infection using colostrum includes administering an effective amount of colostrum to a subject in need thereof. The infection can be caused by G+ or G− bacteria. The colostrum administered may be selected from the group consisting of bovine colostrum, camel colostrum, and a mixture of bovine colostrum and camel colostrum. The bacterial infection may be selected from the group consisting of Staphylococcus aureus subs. aureus Rosenbach, Escherichia coli, Pseudomonas aeruginosa, and Methicillin-resistant Staphylococcus aureus. A colostrum composition can include a mixture of bone and camel colostrum and a pharmaceutically acceptable carrier.

## Claims

### Claim 1

A method of treating a bacterial infection using colostrum, comprising:
providing a therapeutically effective amount of lyophilized colostrum, the lyophilized colostrum made by:
collecting colostrum from the mammary gland of a mammal;
freezing the colostrum at a temperature of at least −20° C. for at least a week;
thawing the colostrum for at least 8 hours;
lyophilizing the colostrum; and
suspending the lyophilized colostrum in a saline solution to provide a colostrum composition;
identifying a subject in need of immune stimulation, and
administering the therapeutically effective amount of the lyophilized colostrum to said subject;
wherein the administration of the lyophilized colostrum results in an increase in the circulating levels of one or more immune system cytokines.

### Claim 2 (depends on 1)

The method of treating an infection using colostrum according to claim 1, wherein the lyophilized colostrum comprises bovine colostrum.

### Claim 3 (depends on 1)

The method of treating an infection using colostrum according to claim 1, wherein the lyophilized colostrum comprises camel colostrum.

### Claim 4 (depends on 1)

The method of treating an infection using colostrum according to claim 1, wherein the lyophilized colostrum comprises a mixture of bovine colostrum and camel colostrum.

### Claim 5 (depends on 1)

The method of treating an infection using colostrum according to claim 1, wherein the immune system cytokines comprise IFN-γ.

### Claim 6 (depends on 1)

The method of treating an infection using colostrum according to claim 1, wherein the immune system cytokines comprise TNF-α.

### Claim 7 (depends on 1)

The method of treating an infection using colostrum according to claim 1, wherein the immune system cytokines comprise IL-10.

### Claim 8 (depends on 1)

The method of treating an infection using colostrum according to claim 1, further comprising preventing the lethal effect of a bacterium.

### Claim 9 (depends on 8)

The method of treating an infection using colostrum according to claim 8, wherein the bacterium is E. coli.

### Claim 10 (depends on 8)

The method of treating an infection using colostrum according to claim 8, wherein the bacterium is P. aeruginosa.

### Claim 11 (depends on 8)

The method of treating an infection using colostrum according to claim 8, wherein the bacterium is S. aureus.

### Claim 12 (depends on 8)

The method of treating an infection using colostrum according to claim 8, wherein the bacterium is MRSA.

### Claim 13 (depends on 1)

The method of treating an infection using colostrum according to claim 1, wherein the subject is a rat.

### Claim at position 14

14-20. (canceled)