# US 2021/0275582 A1 · Composition of nutrition supplementation for nutritional deficiencies and method of use therefore

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2021/0275582 A1
- Document ID: US20210275582A1
- Status: Published application
- Kind: A1
- Application number: 17/303,200
- Filed: 2021-05-24
- Published: 2021-09-09
- Earliest claimed: 2010-05-26
- Assignees: Morehouse School of Medicine
- Applicants: Morehouse School of Medicine
- Inventors: Jacqueline Hibbert; Jonathan K. Stiles; Kayellen Umeakunne; Hyacinth I. Hyacinth
- Web page: https://patentgrep.com/patent/US20210275582A1

## CPC

- A61K 33/32: Manganese; Compounds thereof
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/115: Fatty acids or derivatives thereof; Fats or oils
- A23L 33/15: Vitamins
- A23L 33/155: Vitamins A or D
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/17: Amino acids, peptides or proteins
- A23L 33/175: Amino acids
- A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)}
- A61K 31/015: carbocyclic
- A61K 31/07: Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203)
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 31/4172: Imidazole-alkanecarboxylic acids, e.g. histidine
- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A61K 31/51: Thiamines, e.g. vitamin B1
- A61K 31/525: Isoalloxazines, e.g. riboflavins, vitamin B2
- A61K 31/59: Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K 31/675: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms
- A61K 31/714: Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/18: Iodine; Compounds thereof
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/26: Iron; Compounds thereof
- A61K 33/30: Zinc; Compounds thereof
- A61K 36/88: Liliopsida (monocotyledons)
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 7/06: Antianaemics
- A61P 31/18: for HIV
- A61P 35/00: Antineoplastic agents
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A nutritional supplement composition for treating nutritional deficiencies caused by a medical condition in subjects is disclosed. The present application further discloses a method of using a nutritional supplements composition for treating a subject with complications resulting from sickle cell anemia. The method comprises administering to a subject an effective amount of the nutritional supplement.

## Claims

### Claim 1

A method for treating conditions associated with abnormally slow energy metabolism or high energy requirement, comprising:
administering to a subject in need of such treatment a daily nutritional supplement having total calories of about 700-980 kcal, wherein about 10-20% of the total calories are derived from protein, about 25-40% of the total calories are derived from fat, and about 45-65% of the total calories are derived from carbohydrate.

### Claim 2 (depends on 1)

The method of claim 1, wherein the conditions associated with abnormally slow energy metabolism include malnutrition, anorexia, cancers, AIDS and aging.

### Claim 3 (depends on 1)

The method of claim 1, wherein the conditions associated with high energy requirement include sickle cell anemia, pregnancy, lactation, growth, exercise, infectious diseases and recovery from surgical and other injuries.

### Claim 4 (depends on 3)

The method of claim 3, wherein the condition associated with high energy requirement is sickle cell anemia.

### Claim 5 (depends on 1)

The method of claim 1, wherein the nutritional supplement is administered orally in the form of a snack.

### Claim 6 (depends on 5)

The method of claim 5, wherein the nutritional supplement is administered orally as the last snack before sleeping.

### Claim 7 (depends on 5)

The method of claim 5, wherein the nutritional supplement is administered as snacks after each meal.

### Claim 8

A nutritional supplement to normal diet for treating conditions associated with abnormally slow energy metabolism or high energy requirement, comprising:
protein in an amount that provides about 10-20% of the total calories;
fat in an amount that provides about 25-40% of the total calories; and
carbohydrate that provides about 45-65% of the total calories.

### Claim 9 (depends on 8)

The nutritional supplement of claim 8, wherein the nutritional supplement comprises:
protein in an amount that provides about 14% of the total calories;
fat in an amount that provides about 32% of the total calories; and
carbohydrate that provides about 54% of the total calories.

### Claim 10 (depends on 8)

The nutritional supplement of claim 8, wherein the nutritional supplement has a total calorie of about 700-980 kcal.

### Claim 11 (depends on 10)

The nutritional supplement of claim 10, wherein the nutritional supplement comprises about 24-34 grams of protein; about 25-35 grams of fat; and about 96-135 grams of carbohydrate.

### Claim 12 (depends on 8)

The nutritional supplement of claim 8, wherein the nutritional supplement further comprises at least one food grade amino acid selected from the group consisting of arginine, histidine, leucine, valine, cysteine and glutamine.

### Claim 13 (depends on 12)

The nutritional supplement of claim 12, wherein the nutritional supplement comprises arginine, histidine, leucine, valine, cysteine and glutamine, and wherein each amino acid is provided at a per diem dose range of 8-14 mg/kg body weight/day.

### Claim 14 (depends on 12)

The nutritional supplement of claim 12, wherein the nutritional supplement comprises arginine, histidine, leucine, valine, cysteine and glutamine, and wherein each amino acid is provided at a per diem dose range of 22-44 mg/kg body weight/day.

### Claim 15 (depends on 12)

The nutritional supplement of claim 12, wherein the nutritional supplement further comprises S-allyl cysteines, S-allyhmercapto cysteine and fructosyl arginine.

### Claim 16 (depends on 12)

The nutritional supplement of claim 12, wherein the nutritional supplement further comprises a garlic extract.

### Claim 17 (depends on 8)

The nutritional supplement of claim 8, wherein the nutritional supplement further comprises one or more antioxidants.

### Claim 18 (depends on 17)

The nutritional supplement of claim 17, wherein the one or more antioxidants is selected from the group consisting of Vitamin A, Vitamin C, Vitamin E, β-carotene and selenium.

### Claim 19 (depends on 17)

The nutritional supplement of claim 17, wherein the one or more antioxidants comprise Vitamin C and Vitamin E.

### Claim 20 (depends on 8)

The nutritional supplement of claim 8, further comprising one or more components selected from the group consisting of: Vitamin A 8,250-250,000 I.U., Vitamin B-1 25-1000 mg, Vitamin B-2 25-1000 mg, Vitamin B-6 25-1000 mg, Vitamin B-12 25-1000 mcg, Vitamin C 25-1000 mg, Vitamin D 100-4000 I.U., Vitamin E 25-1000 I.U., Niacinamide 25-1000 mg, Paraaminobenzoic acid (PABA) 25-1000 mg, Pantothenic Acid 25-1000 mg, Choline Bitartrate 25-1000 mg, Inositol 25-1000 mg, Rutin 8.25-250 mg, Citrus Bioflavonoid Complex 8.25-250 mg, Betaine Hydrochloride 8.25-250 mg, Hesperidin Complex 1.25-50 mg, Folic Acid 100-4000 mcg, Biotin 25-1000 mcg, Calcium 10-400 mg, Iron 8.25-250 mg, Magnesium 5-100 mg, Zinc 5-100 mg, Potassium 3.75-150 mg, Manganese 1.5-60 mg, Iodine 37,5-1500 meg, Chromium 3.75-150 mcg, and Selenium 2.5-100 mcg.

### Claim 21 (depends on 20)

The nutritional supplement of claim 20, further comprising one or more component selected from the group consisting of L-lysine-L-phenylalanine, L-lysine-L-tyrosine, L-histidine-L-lysine-L-tyrosine-L-histidine, and salts thereof at a dose range of 10-150 mg/kg/day.

### Claim 22 (depends on 20)

The nutritional supplement of claim 20, further comprising L-lysine-L-phenylalanine or salts thereof at a dose range of 20-80 mg/kg/day.

### Claim 23 (depends on 8)

The nutritional supplement of claim 8, further comprising thiocyanates in an amount of 100-500 mg.

### Claim 24 (depends on 23)

The nutritional supplement of claim 23, wherein the thiocyanate is mixed with Vitamin B6 at a weight ratio of about 20:1.

### Claim 25 (depends on 8)

The nutritional supplement of claim 8, wherein the nutritional supplement is formulated in a ready-to-dispense single-dose form designed for complete consumption as a snack.

### Claim 26 (depends on 8)

The nutritional supplement of claim 8, wherein the nutritional supplement is formulated in a ready-to-dispense three-dose form designed as a snack after each meal.

### Claim 27 (depends on 8)

The nutritional supplement of claim 8, wherein the nutritional supplement is formulated for complete consumption as a two-pack snack to be taken in the morning and evening.