# US 2021/0275574 A1 · Pharmaceutical composition for preventing or treating inflammatory diseases, containing nitrogen monoxide-sensitive acrylamide-based polymer

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- Number: US 2021/0275574 A1
- Document ID: US20210275574A1
- Status: Published application
- Kind: A1
- Application number: 17/182,504
- Filed: 2021-02-23
- Published: 2021-09-09
- Earliest claimed: 2018-08-30
- Assignees: Postech Academy-Industry Foundation
- Applicants: Postech Academy-Industry Foundation
- Inventors: Won Jong KIM; Ji Won Yeo
- Web page: https://patentgrep.com/patent/US20210275574A1

## CPC

- A61K 9/5146: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides}
- A61K 31/785: Polymers containing nitrogen
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/18: Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to a nitric oxide-responsive acrylamide-based polymer, and more particularly, to an acrylamide-based polymer that is produced using an acrylamide-based monomer and a nitric oxide-sensitive crosslinking agent and allows prevention or treatment of a disease or illness caused by overexpression of nitric oxide.

## Claims

### Claim 1

A pharmaceutical composition for preventing or treating an inflammatory disease, comprising a nitric oxide-sensitive acrylamide-based polymer.

### Claim 2 (depends on 1)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 1,
the acrylamide-based polymer is produced using:
an acrylamide-based monomer;
a crosslinking agent having a structure represented by the following Chemical Formula 1;
a radical initiator; and
a catalyst,
wherein the acrylamide-based polymer has a structure represented by the following Chemical Formula 2:
wherein R1, R2, R3, and R4 each independently represent a hydrogen atom or a C1-C10 substituted or unsubstituted alkyl group; and n represents an integer from 1 to 1,000.

### Claim 3 (depends on 2)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 2, wherein R1, R2, R3, and R4 each independently represent a hydrogen atom.

### Claim 4 (depends on 2)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 2, wherein the acrylamide-based monomer is one or more selected from the group consisting of acrylamide, (meth)acrylamide, N-isopropylacrylamide, N-tertiary butyl acrylamide, 3-hydroxypropyl (meth)acrylamide, 4-hydroxybutyl (meth)acrylamide, 6-hydroxyhexyl (meth)acrylamide, 8-hydroxyoctyl (meth)acrylamide, 2-hydroxyethylhexyl (meth)acrylamide, N-methylol (meth)acrylamide, N,N-dimethylol (meth)acrylamide, N-methoxymethyl (meth)acrylamide, and N-propoxymethyl (meth)acrylamide.

### Claim 5 (depends on 1)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 1, wherein the polymer is in the form of a hydrogel.

### Claim 6 (depends on 5)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 5, wherein the diameter of the hydrogel is 10 nm to 500 nm.

### Claim 7 (depends on 1)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 1, wherein the pharmaceutical composition is an injectable preparation.

### Claim 8 (depends on 1)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 1, wherein the inflammatory disease is a disease in which nitric oxide in the body exhibits a condition of overexpression.

### Claim 9 (depends on 1)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 1, wherein the inflammatory disease is rheumatoid arthritis.

### Claim 10 (depends on 1)

The pharmaceutical composition for preventing or treating an inflammatory disease according to claim 1, wherein the pharmaceutical composition further comprises a biologically active substance, and
the nitric oxide-sensitive acrylamide-based polymer is carrying the biologically active substance.