# US 2021/0275571 A1 · Treatment for obesity with superabsorbent materials

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- Number: US 2021/0275571 A1
- Document ID: US20210275571A1
- Status: Published application
- Kind: A1
- Application number: 17/327,020
- Filed: 2021-05-21
- Published: 2021-09-09
- Earliest claimed: 2018-08-10
- Assignees: Healthall Laboratory, Inc.
- Applicants: Healthall Laboratory, Inc.
- Inventors: Lijun SUN
- Web page: https://patentgrep.com/patent/US20210275571A1

## CPC

- A61K 31/736: Glucomannans or galactomannans, e.g. locust bean gum, guar gum
- A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/146: {with organic macromolecular compounds}
- A61K 31/718: Starch or degraded starch, e.g. amylose, amylopectin
- A61K 31/722: Chitin, chitosan
- A61K 31/723: Xanthans
- A61K 31/729: Agar; Agarose; Agaropectin
- A61K 31/731: Carrageenans
- A61K 31/732: Pectin
- A61K 31/734: Alginic acid
- A61K 36/02: Algae
- A61K 36/04: Rhodophycota or rhodophyta (red algae), e.g. Porphyra
- A61K 36/888: Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/06: Antihyperlipidemics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A treatment for obesity can include: providing a superabsorbent material that includes a porous network structure formed from a mixture of a plurality of water soluble polysaccharides that are not chemically crosslinked together; and administering the superabsorbent material to a subject in an effective amount to provide a treatment for obesity in the subject. The treatment can include at least one of: reducing weight of the subject; reducing rate of weight gain in the subject; or increasing rate of weight loss in the subject. The treatment of obesity can include at least one of: reducing caloric intake into the subject; reducing caloric absorption by the gut of the subject; absorbing caloric material from the gut of the subject into the superabsorbent material; or increasing transfer of caloric material from bloodstream into gut.

## Claims

### Claim 1

A treatment for obesity comprising:
providing a superabsorbent material that includes a porous network structure formed from a mixture of a plurality of water soluble polysaccharides that are not chemically crosslinked together; and
administering the superabsorbent material to a subject in an effective amount to provide a treatment for obesity in the subject.

### Claim 2 (depends on 1)

The method of claim 1, wherein the treatment of obesity includes at least one of:
reducing weight of the subject;
reducing rate of weight gain in the subject; or
increasing rate of weight loss in the subject.

### Claim 3 (depends on 1)

The method of claim 1, wherein the treatment of obesity includes at least one of:
reducing caloric intake into the subject;
reducing caloric absorption by the gut of the subject;
absorbing caloric material from the gut of the subject into the superabsorbent material; or
increasing transfer of caloric material from bloodstream into gut.

### Claim 4 (depends on 1)

The method of claim 1, wherein the superabsorbent material is administered in an effective amount to reduce obesity in the subject, wherein the subject is obese.

### Claim 5 (depends on 1)

The method of claim 1, wherein the superabsorbent material is provided in an effective amount as a prophylactic to inhibit progression of obesity in the subject, wherein the subject is selected from: not obese; developing obesity; obese; or morbidly obese.

### Claim 6 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material so that the subject has a slower rate of body weight gain, wherein the slower rate is compared to the subject having a higher rate of body weight gain prior to being administered the superabsorbent material.

### Claim 7 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material so that the subject has a slower rate of body weight gain when on a high fat diet, wherein the slower rate is compared to the subject having a higher rate of body weight gain when on the high fat diet prior to being administered the superabsorbent material.

### Claim 8 (depends on 1)

The method of claim 1, wherein the subject has a high fat diet prior to being administered the superabsorbent material.

### Claim 9 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material in an effective amount to reduce at least one of:
total cholesterol in the subject;
low-density lipoprotein (LDL) in the subject;
high-density lipoprotein (HDL) in the subject;
fasting insulin level in the subject; or
fasting leptin level in the subject.

### Claim 10 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material in an effective amount to inhibit at least one of:
total cholesterol from increasing in the subject;
low-density lipoprotein (LDL) from increasing in the subject;
high-density lipoprotein (HDL) from increasing in the subject;
fasting insulin level from increasing in the subject; or
fasting leptin level from increasing in the subject.

### Claim 11 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material in an effective amount to reduce a HOMA-IR value for the subject.

### Claim 12 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material in an effective amount to inhibit a HOMA-IR value from increasing for the subject.

### Claim 13 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material in an effective amount to reduce fat in the subject.

### Claim 14 (depends on 1)

The method of claim 1, comprising administering the superabsorbent material in an effective amount to inhibit fat from increasing in the subject.

### Claim 15 (depends on 1)

The method of claim 1, wherein the plurality of water soluble polysaccharides includes at least two of agar, konjac gum, carrageenan, locust bean gum, xanthan gum, tamarind seed gum, guar gum carrageenan, alginate, pectin, gellan gum, chitosan, Arabic gum, and a soluble starch.

### Claim 16 (depends on 1)

The method of claim 1, wherein the plurality of water soluble polysaccharides includes at least two of agar, konjac gum, and carrageenan.

### Claim 17 (depends on 1)

The method of claim 1, wherein the superabsorbent material is administered in a dried and/or powdered form.

### Claim 18 (depends on 1)

The method of claim 1, wherein the superabsorbent material is administered in a hydrated gel form or hydrated liquid form.

### Claim 19

A food composition comprising:
a high fat diet foodstuff; and
a superabsorbent material in the foodstuff, wherein the superabsorbent material includes a porous network structure formed from a mixture of a plurality of water soluble polysaccharides that are not chemically crosslinked together.

### Claim 20

A kit for an obesity treatment comprising:
a superabsorbent material that includes a porous network structure formed from a mixture of a plurality of water soluble polysaccharides that are not chemically crosslinked together; and
instructions for a subject to consume the superabsorbent material in an effective amount to treat obesity.
