# US 2021/0275553 A1 · Use of a cream that protects against the effects of aggressive chemical agents in contact with the skin

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- Number: US 2021/0275553 A1
- Document ID: US20210275553A1
- Status: Published application
- Kind: A1
- Application number: 17/172,434
- Filed: 2021-02-10
- Published: 2021-09-09
- Earliest claimed: 2012-07-18
- Assignees: Prevor International
- Applicants: Prevor International
- Inventors: Joel BLOMET; Laurence MATHIEU; Marie-Claude MEYER
- Web page: https://patentgrep.com/patent/US20210275553A1

## CPC

- A61K 31/69: Boron compounds
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 47/183: {Amino acids, e.g. glycine, EDTA or aspartame}
- A61K 47/20: containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61K 2800/51: Chelating agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The use of an emulsion for protecting the skin against aggressive chemical agents, wherein this emulsion includes at least one amphoteric chelating agent which includes a complex based on aluminium and on ethylenediaminetetraacetic acid or the trisodium salt thereof, having the general formula [Al(Y)Bn]C′Dc with B being OH−, BO2− or H+, Y being a tetracarboxylate which can be protonated four times to form ethylenediaminetetraacetic acid, n being an integer equal to 0, 1, 2 or 3, D being a counterion, preferably Na+, c being an integer equal to 0, 1, 2 or 3 and c′ being a relative number having the same absolute value as c.

## Claims

### Claim 1

A method for protecting the skin against aggressive chemical agents, comprising applying to the skin an emulsion comprising at least one amphoteric chelating agent that comprises a complex based on aluminum and ethylenediaminetetraacetic acid or its trisodium salt having the general formula [Al(Y)Bn]c′Dc with B representing OH−, BO2−, H+, Y representing a tetracarboxylate, which may be protonated four times to form ethylenediaminetetraacetic acid, n representing an integer equal to 0, 1, 2 or 3, D being a counterion, preferably Na+, c being an integer equal to 0, 1, 2 or 3 and c′ being a relative number having the same absolute value as c.

### Claim 2 (depends on 1)

The method of claim 1, wherein the aggressive chemical agent is selected from categories H311, H312, H314, H315, H317 of the CLP regulations (regulation (EC) No. 1272/2008), the products having a pH from 2 to 11.5 and mixtures thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein the aggressive chemical agent is an allergen.

### Claim 4 (depends on 3)

The method of claim 3, wherein the allergen is selected from the group consisting of heavy metals such as Al, As, Cd, Cr, Hg, Ni, Pb, Sr and Te, tetramethylthiuram disulfide, 2-mercaptobenzothiazole, benzyl carbamate, bisphenol, ethyl acrylate, Araldite 506 epoxy resin, hevein, methanal and mixtures thereof.

### Claim 5

A method for preventing contact dermatitides, comprising applying to the skin an emulsion comprising at least one amphoteric chelating agent that comprises a complex based on aluminum and ethylenediaminetetraacetic acid or its trisodium salt having the general formula [Al(Y)Bn]c′Dc with B representing OH−, BO2−, Y representing a tetracarboxylate, which may be protonated four times to form ethylenediaminetetraacetic acid, n representing an integer equal to 0, 1, 2 or 3, D being a counterion, preferably Na+, c being an integer equal to 0, 1, 2 or 3 and c′ being a relative number having the same absolute value as c.

### Claim 6 (depends on 1)

The method of claim 1, wherein the emulsion is applied evenly on the entire area, at a rate of about 0.5 to 5 mg/cm2, preferably about 1 to 3 mg/cm2, and even more preferably about 2 mg/cm2.

### Claim 7 (depends on 1)

The method of claim 1, wherein the emulsion is applied at least 5 minutes, preferably at least 10 minutes and even more preferably at least 15 minutes before contact with an aggressive chemical agent.

### Claim 8 (depends on 1)

The method of claim 1, wherein the application of the emulsion is renewed at most every 4 hours, preferably at each washing of the hands.

### Claim 9 (depends on 1)

The method of claim 1, wherein the concentration of amphoteric chelating agent is from 0.01 to 5 wt % based on the total weight of the emulsion.

### Claim 10 (depends on 1)

The method of claim 1, wherein the amphoteric chelating agent is stabilized with an amino acid selected from the group consisting of glycine, histidine, arginine, lysine, phenylalanine, alanine, isoleucine, leucine, methionine, proline, valine, tryptophan, serine, glutamine, cystine and mixtures thereof.

### Claim 11 (depends on 1)

The method of claim 1, wherein the emulsion comprises at least one surfactant, which may be hydrophobic with an HLB from 3 to 10 or hydrophilic with an HLB from 11 to 18.

### Claim 12 (depends on 11)

The method of claim 11, wherein the concentration of surfactant is from 0.1 to 10 wt %, preferably from 0.5 to 5 wt %, and even more preferably from 1 to 3 wt % based on the total weight of the emulsion.

### Claim 13 (depends on 1)

The method of claim 1, wherein said emulsion is an oil-in-water emulsion.

### Claim 14 (depends on 1)

The emulsion as defined in claim 1 for use thereof for protecting the skin against aggressive chemical agents.

### Claim 15 (depends on 5)

The method of claim 5, wherein the emulsion is applied evenly on the entire area, at a rate of about 0.5 to 5 mg/cm2, preferably about 1 to 3 mg/cm2, and even more preferably about 2 mg/cm2.

### Claim 16 (depends on 5)

The method of claim 5, wherein the amphoteric chelating agent is stabilized with an amino acid selected from the group consisting of glycine, histidine, arginine, lysine, phenylalanine, alanine, isoleucine, leucine, methionine, proline, valine, tryptophan, serine, glutamine, cystine and mixtures thereof.

### Claim 17 (depends on 5)

The method of claim 5, wherein the emulsion comprises at least one surfactant, which may be hydrophobic with an HLB from 3 to 10 or hydrophilic with an HLB from 11 to 18.

### Claim 18 (depends on 5)

The method of claim 5, wherein said emulsion is an oil-in-water emulsion.