# US 2021/0275544 A1 · Gallium in the treatment of coronavirus disease > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0275544 A1 - Document ID: US20210275544A1 - Status: Published application - Kind: A1 - Application number: 16/906,542 - Filed: 2020-06-19 - Published: 2021-09-09 - Earliest claimed: 2020-03-05 - Inventors: Lawrence Richard Bernstein - Web page: https://patentgrep.com/patent/US20210275544A1 ## CPC - A61K 31/555: containing heavy metals, e.g. hemin, hematin, melarsoprol - A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration} - A61K 9/0078: {for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions} - A61K 9/08: Solutions {(composition of solutions A61K47/00)} - A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)} - A61K 33/24: Heavy metals; Compounds thereof - A61P 11/00: Drugs for disorders of the respiratory system - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Provided are compositions and methods to treat or prevent coronavirus disease, including Covid-19. The methods comprise the administration of pharmaceutically acceptable gallium compounds. A preferred method is the oral administration of gallium maltolate, and another preferred method is inhalation of an aerosolized solution of gallium maltolate into the bronchi and lungs.. Also provided are methods to destroy or otherwise inactivate coronaviruses on or in the body of an individual, on any surface, in any liquid, or in any gas including air, by direct contact with a gallium compound or with gallium in solution as a liquid or vapor. ## Claims ### Claim 1 A method for treating a disease caused by a coronavirus in an individual afflicted with such a condition, comprising administering to the individual a therapeutically effective amount of a composition comprising a pharmaceutically acceptable gallium compound. ### Claim 2 (depends on 1) The method of claim 1, wherein the disease is Covid-19. ### Claim 3 (depends on 1) The method of claim 1, wherein the gallium compound is selected from the group consisting of gallium hydroxypyrones including gallium maltolate, gallium 8-quinolinolate, gallium citrate, gallium acetate, gallium tartrate, gallium gluconate, gallium nitrate, gallium oxide, gallium hydroxide, gallium oxide hydroxide, gallium chloride, gallium sulfate, gallium polyalcohols such as gallium xylitol, gallium palmitate, gallium succinate, gallium pyridinones, gallium porphyrins such as gallium protoporphyrin IX (PPIX), gallium pyridoxal isonicotinoyl hydrazone, gallium complexes of kenpaullone and its derivatives, and [bis(2-acetylpyridine 4N-dimethylthiosemicarbazone) gallium(III), gallium(III) tetrachloride]. ### Claim 4 (depends on 3) The method of claim 3, wherein the gallium compound is gallium maltolate. ### Claim 5 (depends on 3) The method of claim 3, wherein the gallium compound is gallium 8-quinolinolate. ### Claim 6 (depends on 3) The method of claim 3, wherein the gallium compound is gallium nitrate. ### Claim 7 (depends on 3) The method of claim 3, wherein the gallium compound is gallium citrate. ### Claim 8 A method for destroying or otherwise inactivating coronaviruses on or in the body of an individual, on any surface, in any liquid, or in any gas including the air, by direct contact with a gallium compound or with gallium in solution as a liquid or vapor. ### Claim 9 (depends on 8) The method of claim 8, wherein the coronavirus is SARS-CoV-2. ### Claim 10 (depends on 8) The method of claim 8, wherein the gallium compound is selected from the group consisting of gallium hydroxypyrones including gallium maltolate, gallium 8-quinolinolate, gallium citrate, gallium acetate, gallium tartrate, gallium gluconate, gallium nitrate, gallium oxide, gallium hydroxide, gallium oxide hydroxide, gallium chloride, gallium sulfate, gallium polyalcohols such as gallium xylitol, gallium palmitate, gallium succinate, gallium pyridinones, gallium porphyrins such as gallium protoporphyrin IX (PPIX), gallium pyridoxal isonicotinoyl hydrazone, gallium complexes of kenpaullone and its derivatives, and [bis(2-acetylpyridine 4N-dimethylthiosemicarbazone) gallium(III), gallium(III) tetrachloride]. ### Claim 11 (depends on 8) The method of claim 8, wherein the gallium compound is gallium maltolate. ### Claim 12 (depends on 8) The method of claim 8, wherein the gallium compound is gallium nitrate. ### Claim 13 (depends on 8) The method of claim 8, wherein the gallium compound is gallium citrate. ### Claim 14 (depends on 8) The method of claim 8, wherein the gallium compound is gallium 8-quinolinolate. ### Claim 15 (depends on 8) The method of claim 8, wherein the gallium in solution is a solution that contains gallium hydroxypyrones including gallium maltolate, gallium 8-quinolinolate, gallium citrate, gallium acetate, gallium tartrate, gallium gluconate, gallium nitrate, gallium oxide, gallium hydroxide, gallium oxide hydroxide, gallium chloride, gallium sulfate, gallium polyalcohols such as gallium xylitol, gallium palmitate, gallium succinate, gallium pyridinones, gallium porphyrins such as gallium protoporphyrin IX (PPIX), gallium pyridoxal isonicotinoyl hydrazone, gallium complexes of kenpaullone and its derivatives, or [bis(2-acetylpyridine 4N-dimethylthiosemicarbazone) gallium(III), gallium(III) tetrachloride]. ### Claim 16 (depends on 15) The method of claim 15, wherein the gallium in solution is a solution of gallium maltolate. ### Claim 17 (depends on 15) The method of claim 15, wherein the gallium in solution is a solution of gallium nitrate. ### Claim 18 (depends on 15) The method of claim 15, wherein the gallium in solution is a solution of gallium chloride. ### Claim 19 (depends on 15) The method of claim 15, wherein the gallium in solution is a solution of gallium citrate. ### Claim 20 A method for treating Covid-19 in an individual afflicted with such condition, comprising administering to the individual a therapeutically effective amount of a composition comprising gallium maltolate.