# US 2021/0275535 A1 · Antiviral prodrugs and nanoformulations thereof

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- Number: US 2021/0275535 A1
- Document ID: US20210275535A1
- Status: Published application
- Kind: A1
- Application number: 17/303,228
- Filed: 2021-05-24
- Published: 2021-09-09
- Earliest claimed: 2018-10-22
- Assignees: Board of Regents of the University of Nebraska
- Applicants: Board of Regents of the University of Nebraska
- Inventors: Howard Gendelman; Benson Edagwa
- Web page: https://patentgrep.com/patent/US20210275535A1

## CPC

- A61K 31/5365: ortho- or peri-condensed with heterocyclic ring systems
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/146: {with organic macromolecular compounds}
- A61K 9/1641: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers}
- A61K 31/47: Quinolines; Isoquinolines
- A61K 31/4985: Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A61K 31/513: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/553: having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A61K 47/542: {Carboxylic acids, e.g. a fatty acid or an amino acid}
- A61P 31/18: for HIV
- C07D 498/14: Ortho-condensed systems
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention provides prodrugs and methods of use thereof.

## Claims

### Claim 1

A compound of formula I:
or a pharmaceutically acceptable sat thereof,
wherein R is a saturated linear aliphatic chain of a length of 17 carbons.

### Claim 2 (depends on 1)

The compound of claim 1, wherein the compound is
or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

A nanoparticle comprising a compound of claim 1 and a polymer or surfactant.

### Claim 4 (depends on 3)

The nanoparticle of claim 3, wherein the compound is
or a pharmaceutically acceptable salt thereof, and the polymer or surfactant is P407.

### Claim 5 (depends on 1)

A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

### Claim 6 (depends on 5)

A method of treating an HIV infection in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition of claim 5.

### Claim 7 (depends on 6)

The method of claim 6, wherein the pharmaceutical composition is administered via injection.

### Claim 8 (depends on 6)

The method of claim 6, wherein the pharmaceutical composition is administered one time in a 3, 6, 9, 12, 18, or 24 month period.