# US 2021/0275468 A1 · Method of Treatment Or Alleviating Symptoms Of A Disorder With Curcumin

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- Number: US 2021/0275468 A1
- Document ID: US20210275468A1
- Status: Published application
- Kind: A1
- Application number: 17/186,963
- Filed: 2021-02-26
- Published: 2021-09-09
- Earliest claimed: 2020-03-03
- Assignees: Another Chance Nutra, LLC
- Applicants: Another Chance Nutra, LLC
- Inventors: Emek Blair
- Web page: https://patentgrep.com/patent/US20210275468A1

## CPC

- A61K 31/12: Ketones
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/127: Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/343: condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method of treating or alleviating symptoms of disease, disorder or condition associated body wasting in a subject, including disease, disorder or condition associated body wasting in the subject, the disorder or condition identified based on initial measures of body mass, body mass index, or a bloodstream concentration of a substance, orally administering to said subject an amount of curcumin over a period of time effective treat or alleviate the disease, disorder or condition associated body wasting, diminishing or reversing the body wasting in the subject, and assessing efficacy of treating or alleviating symptoms of the disease, disorder or condition associated with body wasting by comparing final measures of body mass, body mass index, or a bloodstream concentration of a substance after the treatment period time to the initial measures of body mass, body mass index, or bloodstream concentration of the substance.

## Claims

### Claim 1

A method of treating or alleviating symptoms of body wasting of a subject, comprising:
identifying said body wasting in said subject; and
orally administering to said subject an amount of curcumin effective to diminish or reverse said body wasting in said subject.

### Claim 2 (depends on 1)

The method of claim 1, wherein said body wasting comprises a disease or disorder associated body wasting.

### Claim 3 (depends on 2)

The method of claim 2, wherein said disease or disorder comprises cancer.

### Claim 4 (depends on 3)

The method of claim 3, wherein said disease or disorder associated body wasting comprises cachexia.

### Claim 5 (depends on 1)

The method of claim 1, further comprising identifying said body wasting by measuring a body mass loss, a body mass index or blood substance.

### Claim 6 (depends on 1)

The method of claim 1, wherein said amount of curcumin comprises an amount of isolated curcumin, an amount of liposomal curcumin, micellular curcumin, a curcumin analog, a curcumin derivative, and combinations thereof.

### Claim 7 (depends on 1)

The method of claim 1, wherein said amount of curcumin occurs within a range of about 10 milligrams per kilogram of body mass of said subject to about 100 mg/kg of body mass in said subject.

### Claim 8 (depends on 7)

The method of claim 7, wherein said amount of curcumin is selected from the group consisting of: about 11 milligrams to about 20 milligrams, about 15 milligrams to about 25 milligrams, about 20 milligrams to about 30 milligrams, about 25 milligrams to about 35 milligrams, about 30 milligrams to about 40 milligrams, about 35 milligrams to about 45 milligrams, about 40 milligrams to about 50 milligrams, about 45 milligrams to about 55 milligrams, about 50 milligrams to about 60 milligrams, about 55 milligrams to about 65 milligrams, about 60 milligrams to about 70 milligrams, about 65 milligrams to about 75 milligrams, about 70 milligrams to about 80 milligrams, about 75 milligrams to about 85 milligrams, about 80 milligrams to about 90 milligrams, about 85 milligrams to about 95 milligrams, or combinations thereof.

### Claim 9 (depends on 1)

The method of claim 1, wherein said amount of curcumin admixed with an amount of cannabinoid.

### Claim 10 (depends on 9)

The method of claim 9, where said amount of cannabinoid is selected from the group consisting of cannabinol, cannabinolic acid, Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid, Δ(9)-cannabidiol, Δ(9)-tetrahydrocannabidiolic acid, Δ(8)-tetrahydrocannabinol, Δ(8)-tetrahydrocannabinolic acid, Δ(8)-tetrahydrobannabidiol, Δ(8)-tetrahydrocannacbidiolic acid, Δ(9)-tetrahydrocannabivarin, cannabigerol, cannabidigerolic acid, cannabichromene, cannabichromenic acid, cannabicyclol, cannabicyclolic acid, cannabielsoin, cannabitriol, nabilone, equivalents, or combinations thereof.

### Claim 11 (depends on 1)

The method of claim 1, further comprising lipids admixed with said amount of curcumin.

### Claim 12 (depends on 1)

The method of claim 1, further comprising a taste mask.

### Claim 13 (depends on 1)

The method of claim 1, further comprising increasing body mass of said subject.

### Claim 14 (depends on 1)

The method of claim 1, wherein said subject comprises a plurality of subjects, and wherein said method further comprising increasing survival rate in said plurality of subjects.

### Claim 15

A method of treating or alleviating symptoms of a condition in a subject, the method comprising:
identifying said condition in a subject, said condition including an unintended body mass loss;
orally administering to said subject an amount of curcumin over a period of time; and
diminishing or reversing said unintended body mass loss.
