# US 2021/0275065 A1 · Optimizing analyte sensor calibration > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0275065 A1 - Document ID: US20210275065A1 - Status: Published application - Kind: A1 - Application number: 17/328,768 - Filed: 2021-05-24 - Published: 2021-09-09 - Earliest claimed: 2008-09-30 - Assignees: Abbott Diabetes Care Inc. - Applicants: Abbott Diabetes Care Inc. - Inventors: Erwin Satrya Budiman; Wesley Scott Harper; Timothy Christian Dunn - Web page: https://patentgrep.com/patent/US20210275065A1 ## CPC - A61B 5/1495: Calibrating or testing of in-vivo probes - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/7221: {Determining signal validity, reliability or quality (preventing, reducing or removing noise induced by motion artefacts A61B5/7207; noise originating from a therapeutic or surgical apparatus A61B5/7217)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided. ## Claims ### Claim 1 An apparatus, comprising: an in vivo glucose sensor comprising a plurality of electrodes including a working electrode and a silver/silver chloride reference electrode; one or more processors; and at least one memory storing instructions which, when executed by the one or more processors, cause the one or more processors to: store a calibration schedule comprising a plurality of scheduled calibration events for receiving scheduled blood glucose measurements to calibrate the in vivo glucose sensor; upon receiving an unscheduled blood glucose measurement after a successful prior scheduled calibration event but before a next scheduled calibration event, provide a prompt to verify the unscheduled blood glucose measurement; upon receiving a response to the prompt to verify the unscheduled blood glucose measurement, initiate an unscheduled calibration event using the unscheduled blood glucose measurement, and calibrate the in vivo glucose sensor using the unscheduled blood glucose measurement; determine if the unscheduled calibration event successfully calibrated the in vivo glucose sensor; provide a notification if the unscheduled calibration event failed; and update the calibration schedule to override or modify the next scheduled calibration event if the unscheduled calibration event was successful. ### Claim 2 (depends on 1) The apparatus of claim 1, wherein updating the calibration schedule includes modifying the next scheduled calibration event to be a fixed time period after the unscheduled calibration event. ### Claim 3 (depends on 2) The apparatus of claim 2, wherein the fixed period time is the same as a time period between the successful prior scheduled calibration event and the next scheduled calibration event before modification of the next calibration event. ### Claim 4 (depends on 1) The apparatus of claim 1, wherein initiation of the unscheduled calibration event includes validating one or more calibration condition parameters associated with the calibration of the in vivo glucose sensor. ### Claim 5 (depends on 4) The apparatus of claim 4, wherein the one or more calibration condition parameters includes the unscheduled blood glucose measurement. ### Claim 6 (depends on 5) The apparatus of claim 5, wherein the validating includes determining if the unscheduled blood glucose measurement is within an acceptable range. ### Claim 7 (depends on 4) The apparatus of claim 4, wherein the one or more calibration condition parameters includes a glucose rate of change. ### Claim 8 (depends on 1) The apparatus of claim 1, wherein the calibration schedule includes a first predetermined calibration event scheduled 12 hours after a prior scheduled calibration event. ### Claim 9 (depends on 8) The apparatus of claim 8, wherein the calibration schedule includes a second predetermined calibration event scheduled 12 hours after the first scheduled calibration event. ### Claim 10 (depends on 9) The apparatus of claim 9, wherein the calibration schedule includes a third predetermined calibration event scheduled 24 hours after the second scheduled calibration event. ### Claim 11 (depends on 10) The apparatus of claim 10, wherein the calibration schedule includes additional predetermined calibration events scheduled every 24 hours after the third scheduled calibration event. ### Claim 12 (depends on 9) The apparatus of claim 9, wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, update the calibration schedule to modify the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event. ### Claim 13 (depends on 10) The apparatus of claim 10, wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, update the calibration schedule to modify the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event and modify the third predetermined calibration event to be 24 hours after the modified second predetermined calibration event. ### Claim 14 (depends on 11) The apparatus of claim 11, wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, update the calibration schedule to modify the second predetermined calibration event to be scheduled 12 hours after the unscheduled calibration event, modify the third predetermined calibration event to be 24 hours after the modified second predetermined calibration event, and modify the additional predetermined calibration events to be scheduled every 24 hours after the modified third scheduled calibration event. ### Claim 15 (depends on 10) The apparatus of claim 10, wherein upon receiving the unscheduled blood glucose measurement after the second predetermined calibration event and before the third predetermined calibration event, update the calibration schedule to modify the third predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event. ### Claim 16 (depends on 11) The apparatus of claim 11, wherein upon receiving the unscheduled blood glucose measurement after the second predetermined calibration event and before the third predetermined calibration event, update the calibration schedule to modify the third predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event and modify the additional predetermined calibration events to be scheduled every 24 hours after the modified third scheduled calibration event. ### Claim 17 (depends on 1) The apparatus of claim 1, wherein the calibration schedule includes a first predetermined calibration event scheduled 24 hours after a prior scheduled calibration event. ### Claim 18 (depends on 17) The apparatus of claim 17, wherein the calibration schedule includes a second predetermined calibration event scheduled 24 hours after the first scheduled calibration event. ### Claim 19 (depends on 18) The apparatus of claim 18, wherein the calibration schedule includes additional predetermined calibration events scheduled every 24 hours after the second scheduled calibration event. ### Claim 20 (depends on 18) The apparatus of claim 18, wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, update the calibration schedule to modify the second predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event. ### Claim 21 (depends on 19) The apparatus of claim 19, wherein upon receiving the unscheduled blood glucose measurement after the first predetermined calibration event and before the second predetermined calibration event, update the calibration schedule to modify the second predetermined calibration event to be scheduled 24 hours after the unscheduled calibration event and modify the additional predetermined calibration events to be scheduled every 24 hours after the modified second scheduled calibration event. ### Claim 22 (depends on 1) The apparatus of claim 1, wherein the calibration schedule includes a plurality of different time periods between the plurality of scheduled calibration events. ### Claim 23 (depends on 1) The apparatus of claim 1, wherein the instructions which, when executed by the one or more processors, cause the one or more processors to determine the validity of glucose sensor data from the in vivo glucose sensor. ### Claim 24 A method, comprising: storing a calibration schedule comprising a plurality of scheduled calibration events for receiving scheduled blood glucose measurements to calibrate a glucose sensor comprising a plurality of electrodes including a working electrode and a reference electrode, the silver/silver chloride reference electrode; receiving an unscheduled blood glucose measurement after a successful prior scheduled calibration event but before a next scheduled calibration event; providing a prompt to verify the unscheduled blood glucose measurement; receiving a response to the prompt to verify the unscheduled blood glucose measurement, initiating an unscheduled calibration event using the unscheduled blood glucose measurement, and calibrating the glucose sensor using the unscheduled blood glucose measurement; determining if the unscheduled calibration event successfully calibrated the glucose sensor; providing a notification if the unscheduled calibration event failed; and updating the calibration schedule to override or modify a next scheduled calibration event if the unscheduled calibration event was successful. ### Claim 25 (depends on 24) The method of claim 24, wherein updating the calibration schedule includes modifying the next scheduled calibration event to be a fixed time period after the unscheduled calibration event. ### Claim 26 (depends on 25) The method of claim 25, wherein the fixed period time is the same as a time period between the successful prior scheduled calibration event and the next scheduled calibration event before modification. ### Claim 27 (depends on 24) The method of claim 24, wherein initiation of the unscheduled calibration event includes validating one or more calibration condition parameters associated with the calibration of the glucose sensor. ### Claim 28 (depends on 27) The method of claim 27, wherein the one or more calibration condition parameters includes the unscheduled blood glucose measurement. ### Claim 29 (depends on 28) The method of claim 28, wherein the validating includes determining if the unscheduled blood glucose measurement is within an acceptable range. ### Claim 30 (depends on 27) The method of claim 27, wherein the one or more calibration condition parameters includes a glucose rate of change.