# US 2021/0275040 A1 · Ultrasound-based guidance for photoacoustic measurements and associated devices, systems, and methods

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- Number: US 2021/0275040 A1
- Document ID: US20210275040A1
- Status: Published application
- Kind: A1
- Application number: 17/193,470
- Filed: 2021-03-05
- Published: 2021-09-09
- Earliest claimed: 2020-03-05
- Assignees: Koninklijke Philips N.V.
- Applicants: Koninklijke Philips N.V.
- Inventors: Jonathan Fincke; Balasundar Iyyavu Raju; Jonathan Thomas Sutton; Shriram Sethuraman
- Web page: https://patentgrep.com/patent/US20210275040A1

## CPC

- A61B 5/026: Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)}
- A61B 5/0095: {by applying light and detecting acoustic waves, i.e. photoacoustic measurements}
- A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)}
- A61B 5/489: {Blood vessels}
- A61B 5/7285: {for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal}
- A61B 5/7425: {Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image}
- A61B 8/488: {involving Doppler signals}
- A61B 8/5246: {combining images from the same or different imaging techniques, e.g. color Doppler and B-mode}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Systems, devices, and methods for performing photoacoustic measurements using ultrasound-based guidance are provided. In one embodiment, an imaging system includes: an ultrasound imaging probe comprising an ultrasound transducer array, a processor circuit in communication with the ultrasound imaging probe, and a light source configured to emit light. The processor circuit receives first ultrasound data representative of an anatomical feature within a field of view, identifies a location of the anatomical feature within the field of view, and performs a photoacoustic measurement using the identified location of the anatomical feature. Performing the photoacoustic measurement includes: controlling the light source to emit light into the field of view and processing second ultrasound data representative of photoacoustic energy generated in the anatomical feature by the light source. The processor circuit then outputs a graphical representation of the photoacoustic measurement to a display.

## Claims

### Claim 1

An imaging system, comprising:
an ultrasound imaging probe comprising an ultrasound transducer array configured to emit ultrasound energy toward an anatomical feature within a field of view of the ultrasound transducer array; and
a processor circuit in communication with the ultrasound imaging probe and a light source configured to emit light at an orientation with respect to the field of view, wherein the processor circuit is configured to:
receive first ultrasound data obtained by the ultrasound imaging probe, wherein the first ultrasound data is representative of the anatomical feature within the field of view;
identify, by image processing of the first ultrasound data, a location of the anatomical feature within the field of view;
perform a photoacoustic measurement using the identified location of the anatomical feature within the field of view, wherein performing the photoacoustic measurement includes:
controlling the light source to emit the light into the field of view; and
processing second ultrasound data obtained by the ultrasound imaging probe, wherein the second ultrasound data is representative of photoacoustic energy generated in the anatomical feature by the light source; and
output a graphical representation of the photoacoustic measurement to a display in communication with the processor circuit.

### Claim 2 (depends on 1)

The system of claim 1, wherein the first ultrasound data comprises at least one of B-mode data or Doppler data, and wherein the processor circuit is configured to identify the location of the anatomical feature using the B-mode data and the Doppler data.

### Claim 3 (depends on 1)

The system of claim 1, wherein the processor circuit is configured to:
determine, based on the identified location of the anatomical feature, a gate for processing the second ultrasound data; and
perform the photoacoustic measurement using the gate.

### Claim 4 (depends on 3)

The system of claim 3, wherein the gate comprises a temporal gate.

### Claim 5 (depends on 3)

The system of claim 3, wherein the gate comprises a spatial gate.

### Claim 6 (depends on 5)

The system of claim 5, wherein the first ultrasound data comprises Doppler data, and wherein the processor circuit is configured to:
determine a region of flow in the anatomical feature based on the Doppler data; and
determine the spatial gate based on the region of flow.

### Claim 7 (depends on 1)

The system of claim 1, further comprising an actuator coupled to the light source and configured to adjust at least one of a position or an orientation of the light source relative to the field of view of the ultrasound transducer array.

### Claim 8 (depends on 7)

The system of claim 7, wherein the actuator is communicatively coupled to the processor circuit, and wherein the processor circuit is configured to control the actuator, based on the identified location of the anatomical feature, to adjust the at least one of the position or orientation of the light source relative to the field of view of the ultrasound transducer array.

### Claim 9 (depends on 8)

The system of claim 8, wherein the processor circuit is configured to control the actuator, based on the identified location of the anatomical feature, to advance the light source toward the anatomical feature such that tissue between the anatomical feature and the light source is deformed.

### Claim 10 (depends on 1)

The system of claim 1, wherein the light source comprises a plurality of light elements positioned at different locations with respect to the ultrasound transducer array, and wherein the processor circuit is configured to select, based on the identified location of the anatomical feature, one or more light elements of the plurality of light elements to perform the photoacoustic measurement.

### Claim 11 (depends on 1)

The system of claim 1, wherein the processor circuit is configured to:
generate, using the identified location of the anatomical feature, a user instruction to reposition and least one of the light source or the ultrasound imaging probe; and
output the user instruction to the display.

### Claim 12 (depends on 1)

The system of claim 1, wherein the processor circuit is configured to:
generate a first image of the anatomical feature using the first ultrasound data;
generate a second image of the anatomical feature using the second ultrasound data; and
output the co-registered first and second images to the display.

### Claim 13 (depends on 1)

The system of claim 1, wherein the processor circuit is configured to receive the first ultrasound data and the second ultrasound data at a same time.

### Claim 14 (depends on 1)

The system of claim 1, wherein the processor circuit is configured to receive the first ultrasound data and the second ultrasound data at different times in an interleaved fashion.

### Claim 15 (depends on 1)

The system of claim 1, further comprising the light source.

### Claim 16 (depends on 15)

The system of claim 15, wherein the light source is coupled to the ultrasound imaging probe.

### Claim 17

A method for ultrasound imaging, comprising:
receiving, by a processor circuit, first ultrasound data obtained by an ultrasound imaging probe comprising an ultrasound transducer array configured to emit ultrasound energy toward an anatomical feature within a field of view of the ultrasound transducer array, wherein the first ultrasound data is representative of the anatomical feature within the field of view;
identifying, by image processing of the first ultrasound data, a location of the anatomical feature within the field of view;
performing a photoacoustic measurement using the identified location of the anatomical feature within the field of view, wherein performing the photoacoustic measurement includes:
controlling a light source in communication with the processor circuit to emit light into the field of view at an orientation with respect to the field of view; and
processing second ultrasound data obtained by the ultrasound imaging probe, wherein the second ultrasound data is representative of photoacoustic energy generated in the anatomical feature by the light source; and
outputting a graphical representation of the photoacoustic measurement to a display in communication with the processor circuit.