# US 2021/0275028 A1 · Identifying existence of oral diseases

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- Number: US 2021/0275028 A1
- Document ID: US20210275028A1
- Status: Published application
- Kind: A1
- Application number: 16/812,269
- Filed: 2020-03-07
- Published: 2021-09-09
- Earliest claimed: 2020-03-07
- Assignees: Vitrix Health INC.
- Applicants: Vitrix Health INC.
- Inventors: Ayush Kumar; Aashay Patel; Mark Daniel O'Connor; William Widjaja
- Web page: https://patentgrep.com/patent/US20210275028A1

## CPC

- A61B 5/0013: {Medical image data (A61B1/00011, A61B6/56, A61B8/56 take precedence)}
- A61B 5/0088: {for oral or dental tissue}
- A61B 5/0017: {transmitting optical signals}
- A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet}
- A61B 5/004: {adapted for image acquisition of a particular organ or body part (A61B5/0082 takes precedence; arrangements for optical scanning A61B5/0062)}
- A61B 5/4552: {Evaluating soft tissue within the mouth, e.g. gums or tongue}
- A61B 5/6898: {Portable consumer electronic devices, e.g. music players, telephones, tablet computers}
- A61B 5/7264: {Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems}
- G16H 30/40: for processing medical images, e.g. editing
- G16H 40/63: for local operation
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- G16H 50/30: for calculating health indices; for individual health risk assessment
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

Aspects of the present disclosure are directed to identifying existence of oral diseases. In an embodiment, a light source operable to provide light in one of multiple of wavelength bands is provided. The light with the corresponding wavelength band of the multiple wavelength bands accentuates a corresponding feature indicative of a respective set of diseases. The light source may be further operated to generate a first light with a desired wavelength band to illuminate a target area in a mouth of a subject, and an image formed by the reflected light from the target area may be examined for the existence of an oral disease corresponding to the desired wavelength band.

## Claims

### Claim 1

A method of identifying existence of oral diseases, the method comprising:
providing a light source operable to provide light in one of a plurality of wavelength bands, wherein the light with the corresponding wavelength band of the plurality of wavelength bands accentuates a corresponding feature indicative of a respective set of diseases;
operating said light source to generate a first light with a desired wavelength band to illuminate a target area in a mouth of a subject; and
examining an image formed by the reflected light from the target area for the existence of an oral disease corresponding to the desired wavelength band.

### Claim 2 (depends on 1)

The method of claim 1, wherein said providing and said operating are performed in a mobile phone.

### Claim 3 (depends on 2)

The method of claim 2, wherein said examining is also performed in said mobile phone.

### Claim 4 (depends on 3)

The method of claim 3, further comprising:
operating a filter switching mechanism to position an optical filter in the path of said reflected light,
wherein the filter additionally accentuates said corresponding feature.

### Claim 5 (depends on 4)

The method of claim 4, wherein said respective disease is one of tooth cavity, gum disease, oral mucosal abnormality, and hyper-keratinized and dysplastic lesions.

### Claim 6 (depends on 5)

The method of claim 5, wherein said operating operates said light source to generate said first light with a wavelength of about 405 nanometers (nm) and said operating a filter switching mechanism positions a band-pass optical filter having a pass band centered at around 540 nm in the path of said reflected light to enable identification of said hyper-keratinized and dysplastic lesions,
wherein said operating operates said light source to generate said first light with wavelengths of 415 nm and 540 nm, and said operating a filter switching mechanism positions an all-pass optical filter in the optical path of said reflected light to enable identification of said oral mucosal abnormality.

### Claim 7 (depends on 5)

The method of claim 5, wherein said operating operates said light source to generate white light, and said operating a filter switching mechanism positions an all-pass optical filter in the light path of said reflected light to generate a red, green, blue (RGB) image to enable identification of said gum disease.

### Claim 8 (depends on 7)

The method of claim 7, wherein said identification of said gum disease further comprises:
removing red and blue components of said RGB image to obtain a green image;
converting said green image to a grayscale image;
applying a histogram equalizer function to said grayscale image to cause equalization and normalization of said grayscale image, and increase contrast in the grayscale image, said applying said histogram equalizer function generating a normalized and contrasted image;
passing said normalized and contrasted image to a pre-trained deep neural net algorithm to classify whether said normalized and contrasted image indicates presence of disease, wherein said deep neural net algorithm uses a supervised CNN (convolutional neural network);
if said pre-trained deep neural net algorithm indicates presence of disease, then passing said normalized and contrasted image through a thresholding algorithm to create a pixelated image that highlights the areas that have high contrast values; and
passing said pixelated image to a contour recognition algorithms to identify and highlight diseased areas in said pixelated image.

### Claim 9 (depends on 8)

The method of claim 8, further comprising computing a patient's risk of oral cancer according to an equation: ocr=(w1*s)+(w2*ct)+(w3*cqwt)+(w4*cqnt)+(w5*al)+(w6*fc)+(w7*fh)+(w8*rm),
wherein s equals 1 if said patient smokes and equals 0 if said patient does not smoke,
wherein ct equals 1 if said patient chews tobacco and equals 0 if said patient does not chew tobacco,
wherein cqwt equals 1 if said patient chews quid with tobacco and equals 0 if said patient does not chew quid with tobacco,
wherein cqnt equals 1 if said patient chews quid without tobacco and equals 0 if said patient does not chew quid without tobacco,
wherein al equals 1 if said patient consumes alcohol and equals 0 if said patient does not consume alcohol,
wherein fc equals 1 if said patient consumes fruit and equals 0 if said patient does not consume fruit,
wherein fh equals 1 is said patient has a family history of cancer and equals 0 if said patient does not have a family history of cancer,
wherein rm equals 1 if said patient does not rinse mouth after eating and equals 0 if said patient rinses mouth after eating,
wherein ocr equals patient's risk of oral cancer,
wherein said equation is based on data from other oral cancer patients, and
w1, w2, w3, w4, w5, w6, w7 and w8 are weights pre-calculated using a regression technique.

### Claim 10

A mobile phone comprising:
a light source operable to provide light with one of a plurality of wavelength bands, wherein the light with the corresponding wavelength band of the plurality of wavelength bands accentuates a corresponding feature indicative of a respective disease;
a processor to operate said light source to generate a first light with a desired wavelength band to illuminate a target area in a mouth of a subject; and
an image capture apparatus to form an image based on the reflected light from the target area.

### Claim 11 (depends on 10)

The mobile phone of claim 10, wherein the processor is operable to examine an image formed by the reflected light from the target area for the existence of an oral disease corresponding to the desired wavelength band.

### Claim 12 (depends on 10)

The mobile phone of claim 10, wherein said processor executes a software application which provides a user interface for a user to specify said desired wavelength band, said mobile phone further comprising:
a control board to receive a command from said processor and to control said light source to generate said first light with said desired wavelength band,
wherein said processor receives a user input specifying said desired bandwidth from said user interface and generates said command.

### Claim 13 (depends on 12)

The mobile phone of claim 12, further comprising a filter switching mechanism comprising a plurality of optical filters, wherein said processor is further operable to cause said filter switching mechanism to position a first filter of said plurality of optical filters in the path of said reflected light,
wherein said first filter additionally accentuates said corresponding feature,
wherein said user input also specifies said first filter,
wherein said control board is further designed to control said filter switching mechanism to position said first filter in the path of said reflected light in response to receipt of said command from said processor.

### Claim 14 (depends on 13)

The mobile phone of claim 13, wherein said respective disease is one of tooth cavity, gum disease, oral mucosal abnormality, and hyper-keratinized and dysplastic lesions.

### Claim 15 (depends on 14)

The mobile phone of claim 14, wherein said processor is designed to operate said light source to generate said first light with a wavelength of 405 nanometers (nm) and position a band-pass optical filter having a pass band centered at 540 nm in the path of said reflected light to enable identification of said hyper-keratinized and dysplastic lesions.

### Claim 16 (depends on 14)

The mobile phone of claim 14, wherein said processor is designed to operate said light source to generate said first light with wavelengths of 415 nm and 540 nm, and position an all-pass optical filter in the optical path of said reflected light to enable identification of said oral mucosal abnormality.

### Claim 17 (depends on 14)

The mobile phone of claim 14, wherein said processor operates said light source to generate white light, and position an all-pass optical filter in the light path of said reflected light to generate a red, green, blue (RGB) image to enable identification of said gum disease.

### Claim 18 (depends on 17)

The mobile phone of claim 17, wherein to enable identification of said gum disease, said processor is further operable to:
remove red and blue components of said RGB image to obtain a green image;
convert said green image to a grayscale image;
apply a histogram equalizer function to said grayscale image to cause equalization and normalization of said grayscale image, and increase contrast in said grayscale image to generate a normalized and contrasted image;
pass said normalized and contrasted image to a pre-trained deep neural net algorithm to classify whether said normalized and contrasted image indicates presence of disease, wherein said deep neural net algorithm uses a supervised CNN (convolutional neural network);
if said pre-trained deep neural net algorithm indicates presence of disease, then to pass said normalized and contrasted image through a thresholding algorithm to create a pixelated image that highlights the areas that have high contrast values; and
pass said pixelated image to a contour recognition algorithms to identify and highlight diseased areas in said pixelated image.

### Claim 19

A non-transitory machine readable medium storing one or more sequences of instructions for enabling a user to identify existence of oral diseases using a system, wherein execution of said one or more instructions by one or more processors contained in said system enables said system to perform the actions of:
providing a light source operable to provide light in one of a plurality of wavelength bands, wherein the light with the corresponding wavelength band of the plurality of wavelength bands accentuates a corresponding feature indicative of a respective set of diseases;
operating said light source to generate a first light with a desired wavelength band to illuminate a target area in a mouth of a subject; and
examining an image formed by the reflected light from the target area for the existence of an oral disease corresponding to the desired wavelength band.

### Claim 20 (depends on 19)

The non-transitory machine readable medium of claim 19, wherein said system is a mobile phone, said non-transitory machine readable medium further comprising instructions for:
operating a filter switching mechanism to position an optical filter in the path of said reflected light,
wherein the filter additionally accentuates said corresponding feature.