# US 2021/0274825 A1 · Low calorie nutritional compositions for maintaining metabolic balance > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0274825 A1 - Document ID: US20210274825A1 - Status: Published application - Kind: A1 - Application number: 17/330,158 - Filed: 2021-05-25 - Published: 2021-09-09 - Earliest claimed: 2010-10-01 - Assignees: Children`s Hospital & Research Center at Oakland; The United States of America as represented by the Secretary of Agriculture - Applicants: Children`s Hospital & Research Center at Oakland; The United States of America, as Represented by the Secretary of Agriculture - Inventors: Bruce Ames; Mark Shigenaga; Michele Mietus Snyder; Joyce McCann; Tara McHugh; Donald A. Olson - Web page: https://patentgrep.com/patent/US20210274825A1 ## CPC - A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula} - A23L 19/09: {Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks (A23L19/01, A23L19/10, A23L27/63 and A23L21/00 take precedence)} - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A23L 33/12: Fatty acids or derivatives thereof - A23L 33/15: Vitamins - A23L 33/155: Vitamins A or D - A23L 33/16: Inorganic salts, minerals or trace elements - A23L 33/175: Amino acids - A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres - A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)} - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract The present invention provides nutritional compositions (for example, sensorially acceptable nutritional compositions) that comprise a fruit component, a fiber component, and a micronutrient component. Also provided are methods of making and using the nutritional compositions. ## Claims ### Claim 1 A method for increasing high density lipoprotein (HDL) particles and decreasing low density lipoprotein (LDL) particles in a patient, the method comprising orally administering to the patient an amount of a nutritional composition effective to increase HDL and to decrease LDL, wherein each daily dose of the nutritional composition comprises between 30 and 500 grams, and wherein the nutritional composition comprises: a) a fruit component, wherein the fruit component is from 20 to 40% (w/w) of the composition; b) a viscous soluble fiber component, wherein the viscous soluble fiber component is from 6 to 8% (w/w) of the composition, and wherein the viscous soluble fiber component is a 1:1 ratio by weight of β-glucan and hydroxypropyl methyl cellulose; c) a vitamin component, wherein the vitamin component comprises: β carotene, wherein the β carotene is from 0.00025% to 0.0010% (w/w) of the composition, vitamin B6, wherein the vitamin B6 is from 0.001% to 0.005% (w/w) of the composition, vitamin B12, wherein the vitamin B12 is from 0.0000015% to 0.000005% (w/w) of the composition, vitamin C, wherein the vitamin C is from 0.35% to 4% (w/w) of the composition, vitamin D, wherein the vitamin D is from 0.000008% to 0.000034% (w/w) of the composition, vitamin E, wherein the vitamin is from 0.008% to 0.034% (w/w) of the composition, vitamin K, wherein the vitamin K is from 0.00005% to 0.0004% (w/w) of the composition, and folate, wherein the folate is from 0.0003% to 0.0015% (w/w) of the composition; d) a mineral component, wherein the mineral component comprises: calcium, wherein the calcium is from 0.5% to 2.0% (w/w) of the composition, magnesium, wherein the magnesium is from 0.2% to about 1% (w/w) of the composition, potassium, wherein the potassium is from 0.2% to about 1% (w/w) of the composition, and zinc, wherein the zinc is from 0.004% to 0.015% (w/w) of the composition; and, e) docosahexaenoic acid (DHA), wherein the DHA is from 0.1% to 1% (w/w) of the composition and wherein DHA is present in an amount between 300 and 500 mg. ### Claim 2 (depends on 1) The method of claim 1, wherein the nutritional composition further comprises whey protein at 1-10% (w/w) of the composition. ### Claim 3 (depends on 1) The method of claim 1, wherein the nutritional composition further comprises glutamine at 2-4% (w/w) of the composition. ### Claim 4 (depends on 1) The method of claim 1, wherein the vitamin component of the nutritional composition further comprises a vitamin selected from the group consisting of: niacin, wherein the niacin is from 0.01% to 0.05% (w/w) of the composition, biotin, wherein the biotin is from 0.00001% to 0.00005% (w/w) of the composition, pantothenic acid, wherein the pantothenic acid is from 0.002% to 0.01% (w/w) of the composition, thiamin, wherein the thiamin is from 0.0006% to 0.004% (w/w) of the composition, choline, wherein the choline is from 0.1 to 0.8% (w/w) of the composition, and riboflavin, wherein the riboflavin is from 0.001% to 0.004% (w/w) of the composition. ### Claim 5 (depends on 1) The method of claim 1, wherein the mineral component of the nutritional composition further comprises a mineral selected from the group consisting of: iron, wherein the iron is from 0.002% to 0.01% (w/w) of the composition, selenium, wherein the selenium is from 0.00001% to 0.00004% (w/w) of the composition, chromium, wherein the chromium is from 0.00001% to 0.0001% (w/w) of the composition, manganese, wherein the manganese is from 0.0025% to 0.01% (w/w) of the composition, and copper, wherein the copper is from 0.0001% to 0.001% (w/w) of the composition. ### Claim 6 (depends on 1) The method of claim 1, wherein the fiber component of the nutritional composition further comprises a water insoluble fiber, wherein the water insoluble fiber is from 5.0% to 40% (w/w) of the composition. ### Claim 7 (depends on 1) The method of claim 1, wherein the nutritional composition further comprises a protein. ### Claim 8 (depends on 1) The method of claim 1, wherein the nutritional composition further comprises a component selected from the group consisting of: chocolate, vanilla and coffee. ### Claim 9 (depends on 1) The method of claim 1, wherein the fruit component of the nutritional composition comprises a concentrate from a berry fruit. ### Claim 10 A method for manufacturing a nutritional composition that increases high density lipoprotein cholesterol (HDL) particles and decreases low density lipoprotein cholesterol (LDL) particles in a patient, the method comprising the step of combining in a single composition of between 30 and 500 grams the following components: a) a fruit concentrate component, wherein the fruit concentrate component is from 20 to 40% (w/w) of the composition; b) a viscous soluble fiber component, wherein the viscous soluble fiber component is from 6 to 8% (w/w) of the composition and is a 1:1 ratio by weight of β-glucan and hydroxypropyl methyl cellulose; and, c) a vitamin component, wherein the vitamin component comprises: β carotene, wherein the β carotene is from 0.00025% to 0.0010% (w/w) of the composition, vitamin B6, wherein the vitamin B6 is from 0.001% to 0.005% (w/w) of the composition, vitamin B12, wherein the vitamin B12 is from 0.0000015% to 0.000005% (w/w) of the composition, vitamin C, wherein the vitamin C is from 0.35% to 4% (w/w) of the composition, vitamin D, wherein the vitamin D is from 0.000008% to 0.000034% (w/w) of the composition, vitamin E, wherein the vitamin is from 0.008% to 0.034% (w/w) of the composition, vitamin K, wherein the vitamin K is from 0.00005% to 0.0004% (w/w) of the composition, and folate, wherein the folate is from 0.0003% to 0.0015% (w/w) of the composition; d) a mineral component, wherein the mineral component comprises: calcium, wherein the calcium is from 0.5% to 2.0% (w/w) of the composition, magnesium, wherein the magnesium is from 0.2% to about 1% (w/w) of the composition, potassium, wherein the potassium is from 0.2% to about 1% (w/w) of the composition, and zinc, wherein the zinc is from 0.004% to 0.015% (w/w) of the composition; and, e) docosahexaenoic acid (DHA), wherein the DHA is from 0.1% to 1% (w/w) of the composition, and wherein DHA is present in an amount between 300 and 500 mg. ### Claim 11 (depends on 1) The method of claim 1, wherein the patient suffers from a disease selected from the group consisting of obesity, diabetes, and metabolic syndrome. ### Claim 12 (depends on 1) The method of claim 1, wherein daily dose is divided into 2 equal parts.