# US 2021/0274824 A1 · Nutritional Treatment for Cancer

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2021/0274824 A1
- Document ID: US20210274824A1
- Status: Published application
- Kind: A1
- Application number: 17/178,979
- Filed: 2021-02-18
- Published: 2021-09-09
- Earliest claimed: 2015-09-21
- Assignees: The Board of Trustees of the Leland Stanford Junior University
- Applicants: The Board of Trustees of the Leland Stanford Junior University
- Inventors: Xiyan Li; Michael P. Snyder; Xin Wang
- Web page: https://patentgrep.com/patent/US20210274824A1

## CPC

- A23L 33/175: Amino acids
- A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)}
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327)
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/525: Isoalloxazines, e.g. riboflavins, vitamin B2
- A61K 31/675: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- G01N 33/5008: {for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics}
- G01N 33/5011: {for testing antineoplastic activity}
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Methods of screening cancerous cells for nutritional weaknesses and methods of treating cancer nutritionally are disclosed. Certain cancers depend on being supplied with one or more nutrients that are non-essential for normal cells. In particular, the invention relates to methods of treating cancer by identifying nutritional weaknesses of cancer cells and using nutritional therapy to suppress cancer by putting a subject on a diet that deprives cancerous cells of a nutrient needed for cancer proliferation and growth. Nutritional therapy can be used to enhance the effectiveness of current cancer treatments.

## Claims

### Claim at position 1

-20. (canceled)

### Claim 21

A method for reducing or eliminating a subject's daily intake of cysteine or cystine, the method comprising subjecting the subject to a low-cysteine diet that reduces the subject's daily intake of cysteine or cystine in food by at least 50%.

### Claim 22 (depends on 21)

The method of claim 21, wherein the low-cysteine diet comprises methionine.

### Claim 23 (depends on 21)

The method of claim 21, wherein the low-cysteine diet comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine.

### Claim 24 (depends on 21)

The method of claim 21, wherein the low-cysteine diet comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine at levels in accordance with United States Recommended Daily Allowances (USRDA) guidelines.

### Claim 25 (depends on 21)

The method of claim 21, further comprising reducing or eliminating the subject's daily intake of at least one amino acid selected from the group consisting of arginine, glutamine, serine, and tyrosine.

### Claim 26 (depends on 21)

The method of claim 21, wherein said subjecting comprises placing said subject on said low-cysteine diet for at least one month.

### Claim 27 (depends on 21)

The method of claim 21, wherein the method is in combination with surgery, radiation therapy, chemotherapy, hormonal therapy, immunotherapy, biologic therapy, or a combination thereof.

### Claim 28 (depends on 21)

The method of claim 21, further comprising administering to the subject one or more therapeutic agents selected from the group consisting of a cysteine/cystine-depleting drug, a cysteine degradation enzyme, a gamma-glutamyl transpeptidase inhibitor, a cysteine/cystine transporter inhibitor, and an inhibitor of cysteine biosynthesis.

### Claim 29 (depends on 21)

The method of claim 21, wherein a cancer is responsive to the low-cysteine diet.

### Claim 30 (depends on 29)

The method of claim 29, wherein the cancer is lung cancer, liver cancer, breast cancer, prostate cancer, colon cancer, pancreatic cancer, head cancer, neck cancer, lymphoma, or leukemia, or a combination thereof.

### Claim 31 (depends on 21)

The method of claim 21, wherein said subject is on said low-cysteine diet until at least a partial tumor response is effected.

### Claim 32 (depends on 21)

The method of claim 21, wherein said subject is a mammal or a human.

### Claim 33 (depends on 21)

The method of claim 21, wherein the low-cysteine diet does not comprise cysteine.

### Claim 34

A meal characterized in that:
(a) it comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine; and
(b) it comprises no more than 50% of cysteine or cystine as compared to a corresponding reference; and
(c) it is a breakfast meal, a lunch meal, a dinner meal, or a snack.

### Claim 35 (depends on 34)

The meal of claim 34, wherein the meal is a pre-packaged meal.

### Claim 36 (depends on 34)

The meal of claim 34, wherein the meal is a cysteine-free meal.

### Claim 37 (depends on 34)

The meal of claim 34, further comprising a low amount of at least one amino acid selected from the group consisting of arginine, glutamine, serine, and tyrosine.

### Claim 38 (depends on 34)

The meal of claim 34, wherein the meal does not contain at least one amino acid selected from the group consisting of arginine, glutamine, serine, and tyrosine.

### Claim 39 (depends on 34)

The meal of claim 34, wherein the meal is a protein-free meal or low-protein meal.

### Claim 40 (depends on 34)

The meal of claim 34, wherein the meal comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine at levels in accordance with United States Recommended Daily Allowances (USRDA) guidelines.