# US 2021/0274789 A1 · Antimicrobial Surface Treatment

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2021/0274789 A1
- Document ID: US20210274789A1
- Status: Published application
- Kind: A1
- Application number: 17/255,198
- Filed: 2019-06-24
- Published: 2021-09-09
- Earliest claimed: 2018-06-22
- Assignees: Kode Biotech Limited
- Applicants: Kode Biotech Limited
- Inventors: Stephen Michael Henry; Pavithra Ranguraman
- Web page: https://patentgrep.com/patent/US20210274789A1

## CPC

- A01N 59/16: Heavy metals; Compounds thereof
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A01N 25/10: Macromolecular compounds
- A01N 33/12: Quaternary ammonium compounds
- A61K 33/38: Silver; Compounds thereof
- A61L 15/26: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)}
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61L 26/0028: {Polypeptides; Proteins; Degradation products thereof}
- A61L 26/0066: {Medicaments; Biocides}
- A61L 27/34: Macromolecular materials
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L 2300/104: Silver, e.g. silver sulfadiazine
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/442: Colorants, dyes
- A61L 2420/02: Methods for coating medical devices
- A61L 2430/12: for dental implants or prostheses
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A method of treating a surface so that the antimicrobial activity of water-soluble antimicrobial agents is retained at the surface despite repeated washing with water is described. The method uses a dispersion of a lipidated polyanionic molecule and one or more antimicrobial agents in an aqueous carrier such as water. The treatment of the surface of the fabric of adhesive bandages and stainless steel is demonstrated using a combination of crystal violet and silver nitrate as the antimicrobial agents. The method has application in the treatment of such surfaces to control microbial growth and the development of biofilms.

## Claims

### Claim 1

A method of treating a surface comprising the steps of:
(a) contacting the surface with a lipidated polyanionic molecule dispersed in a solution of one or more water-dispersible antimicrobial agents; and then
(b) drying the surface,
where the antimicrobial activity of the one or more water-dispersible antimicrobial agents is retained at the surface when the surface is contacted with an aqueous vehicle.

### Claim 2 (depends on 1)

The method of claim 1 where the one or more water-dispersible antimicrobial agents are selected from the group consisting of: silver and salts of hexamethylpararosaniline.

### Claim 3 (depends on 2)

The method of claim 2 where the silver is in the form of silver nitrate (AgNO3).

### Claim 4 (depends on 2, 3)

The method of claim 2 or 3 where the salt of hexamethylpararosaniline is hexamethylpararosaniline chloride (crystal violet).

### Claim 5 (depends on 1)

The method of claim 1 where the surface is selected from the group consisting of ceramics, metals and polymers.

### Claim 6 (depends on 5)

The method of claim 5 where the surface is selected from the group consisting of: the fabric of an adhesive bandage and the stainless steel of a dental or medical implant.

### Claim 7 (depends on 1)

The method of claim 1 where the aqueous vehicle is water.

### Claim 8 (depends on 1)

The method of claim 1 where the lipidated polyanionic molecule is of the structure L-A-M where L is a lipid, A is an optional linker and M is the polyanionic molecule.

### Claim 9 (depends on 8)

The method of claim 8 where L is a lipid selected from the group consisting of: monoacyl-, monoalkyl-, diacyl- and dialkyl-lipids.

### Claim 10 (depends on 9)

The method of claim 9 where the polyanionic molecule is a polycarboxylic molecule.

### Claim 11 (depends on 10)

The method of claim 10 where the lipidated polyanionic molecule is a lipidated polycarboxylic molecule of the structure:
where F is H or selenocyanate, n is the integer 1, 2 or 4, p is the integer 3, 4 or 5 and R1 and R2 are independently selected from the group consisting of: saturated and mono-unsaturated C16-20-acyl substituents.

### Claim 12

A composition consisting essentially of a water-soluble salt of hexamethylpararosaniline, a water-soluble salt of silver, a lipidated polyanionic molecule and water.

### Claim 13 (depends on 12)

The composition of claim 12 where the lipidated polyanionic molecule is a lipidated polycarboxylic molecule of the structure:
where F is H, n is the integer 1, 2 or 4, p is the integer 3, 4 or 5 and R1 and R2 are independently selected from the group consisting of: saturated and mono-unsaturated O16-20-acyl substituents.

### Claim 14 (depends on 1)

A fabric or dental or surgical implant having a surface treated according to the method of claim 1.

### Claim 15

(canceled)