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AssigneeEvonik Canada Inc.
InventorsAlexandra Piotrowicz, Kyle William Macdonald, Antonio Cillero Rodrigo, Sanjoy Mullick, Jamie Robert Swenor, J. Paul Santerre, Jeannette Ho
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The invention features surfaces formed from a base polymer admixed with an additive of the invention. The surfaces can be resistant to bacterial adhesion. The surfaces of the invention can be applied to: (a) any medical device or material that is implanted in or juxtaposed to a human or animal tissue or body fluid, in vivo or ex vivo, permanently or for a short period, and (b) any useful article, material or device, medical or not, which is to maintain a human or animal health-safe unfouled state of cleanliness over a period of time. In these medical and non-medical applications it is known that undesirable fouling phenomenon can take place which might harm a patient, user or consumer of the compromised device, equipment or material processed by, transported or stored in contamination prone articles, equipment or environments. Such fouling phenomena include biofilm development and bacterial colony development. Such fouling can cause irritation and swelling, allergic reactions, toxic reactions, poisoning or infections.
A method of reducing bacterial adhesion to a polymeric surface formed from a base polymer, the method comprising admixing the base polymer with a compound of any one of formulas (I)-(XXI), wherein bacterial adhesion is reduced by at least 50% relative to the polymeric surface formed from the base polymer in the absence of the compound.
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A method of reducing bacteria mediated salt formation on a polymeric surface of a urine dwelling device, the method comprising (i) providing the polymeric surface formed from an admixture comprising a base polymer admixed with a compound of any one of formulas (I)-(XXI), and (ii) contacting said polymeric surface with urine, wherein salt deposition is reduced by at least 20% under urine dwelling conditions relative to the polymeric surface formed from the base polymer in the absence of the compound.
A method of reducing bacterial biofilm formation on a polymeric surface, the method comprising providing the polymeric surface formed from an admixture comprising a base polymer admixed with a compound of any one of formulas (I)-(XXI), wherein bacterial biofilm formation is reduced by at least 20% relative to the polymeric surface formed from the base polymer in the absence of the compound.
A method of reducing the bacterial bioburden on a polymeric surface, the method comprising admixing a base polymer with a compound of any one of formulas (I)-(XXI) to form the polymeric surface, wherein bioburden is reduced by at least 20% relative to the polymeric surface formed from the base polymer in the absence of the compound.
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A method of reducing bacterial growth rate on a polymeric surface, the method comprising (i) providing a polymeric surface comprising a base polymer admixed with a compound of any one of formulas (I)-(XXI), and (ii) contacting the polymeric surface with an antimicrobial, antiseptic, or disinfectant, wherein the bacterial growth rate is reduced by at least 50% relative to the polymeric surface formed from the base polymer in the absence of the compound.
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A method for reducing the amount of bacterial adhesion on a polymeric surface of an implanted medical device, said method comprising (i) administering to the subject an antimicrobial agent;
A method for reducing the amount of bacteria adhesion on a polymeric surface of an implanted medical device, said method comprising (i) providing a subject that is undergoing treatment with an antimicrobial agent;
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Dependencies are inferred from the claim text.