5-acetamidomethyl-oxazolidinone derivatives for use in the treatment of cancer

A method of treating, preventing or ameliorating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I):

• wherein X is O, S, SO or SO2;
• R1 is hydrogen, except when X is O then R1 can be hydrogen, CN, CO2R6 or a C1-2 alkyl, optionally substituted with OR6, OCOR6, N(R6)2 or NHCOR6;
• R2 is hydrogen, except when X is O and R1 is CH3 then R2 can be H or CH3;
• R3 and R4 are independently hydrogen, F or Cl;
• R5 is hydrogen, C1-8 alkyl optionally substituted with one or more of R7;
• C3-6 cycloalkyl, amino, C1-8 alkylamino, C1-8 dialkylamino or C1-8 alkoxy;
• each R6 is independently hydrogen, C1-8 alkyl optionally substituted with one or more of R7, C3-6 cycloalkyl, amino, C1-8 alkylamino, C1-8 dialkylamino or C1-8 alkoxy;
• each R7 is independently F, Cl, OH, C1-8 alkoxy, C1-8 acyloxy or O—CH2—Ph;
• and n is 0, 1 or 2;
• or a pharmaceutically acceptable salt or solvate thereof.