Methods for treating pten deficient epithelial cancers using a combination of anti-pi3kbeta and anti-immune checkpoint agents
AssigneeDana-Farber Cancer Institute, Inc.
InventorsJean Zhao, Johann Bergholz, Gordon J. Freeman, Thomas M. Roberts
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Abstract
The present invention relates to methods for treating PTEN deficient epithelial cancers using a combination of anti-PI3Kbeta and anti-immune checkpoint agents.
Claims32
A method of treating a subject afflicted with a cancer that is deficient in phosphatase and tensin homolog (PTEN) comprising administering to the subject a therapeutically effective amount of at least one agent that inhibits or blocks both phosphoinositide 3-kinase isoform beta (PI3Kbeta) and an immune checkpoint, wherein the cancer is an epithelial cancer.
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Dependencies are inferred from the claim text.