Application of allopurinol in preparation of drug for treating cancer with high expression of paics gene
OwnerWei ZHU, Wuguang PANinventors
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Abstract
Disclosed is an application of allopurinol in the preparation of a drug for treating a cancer with high expression of a PAICS gene. Through screening by cell biology combined with animal experiments, and by bioinformatics analysis of gene expression of about 10,000 sample data from the TCGA database, It can be found and confirmed that allopurinol has significant anti-cancer and therapeutic effects on the cancer with abnormally high expression of the PAICS gene, including but not limited to, combined chemotherapy for cancer resistance, inhibition of cancer recurrence, improvement of prognosis survival rate, and the like.
Claims11
1-10. (canceled)
A composition for treating the cancer related to high expression of the PAICS gene, wherein the active ingredients of the composition comprise at least one existing anti-tumor drug and allopurinol.
A method for treating or preventing the cancer related to high expression of the PAICS gene, comprising administering a therapeutic or preventive amount of allopurinol to a patient.
Allopurinol for use in the drug for preventing or treating the cancer related to high expression of the PAICS gene.
Dependencies are inferred from the claim text.