Method of and Improved Composition for Treating Triterpene-Responsive Conditions, Diseases or Disorders
AssigneePhoenix Biotechnology, Inc.
InventorsROBERT A. NEWMAN, OTIS C. ADDINGTON, DONALD C. LO, LINDA S. KALTENBACH, PEIYING YANG
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Abstract
A method of treating a triterpene-responsive condition, disease or disorder in a subject by administration of an improved triterpene-based composition is provided. An improved triterpene-based composition comprising at least two or at least three triterpenes present at a molar ratio as described herein is also provided.
Claims13
1) A method of treating a triterpene-responsive condition, disease, or disorder comprising administering to a subject in need thereof a triterpene-based composition comprising a combination of a first triterpene oleanolic acid (OA), a second triterpene ursolic acid (UA), and a third triterpene betulinic acid (BA), wherein each triterpene is independently selected at each occurrence from the free acid form thereof, salt(s) form thereof, derivative(s) thereof, prodrug(s) thereof and/or combination thereof, and wherein the molar ratio of OA:UA:BA is selected from the group consisting of about 10:
- about 1:
- about 1, about 9-11:
- about 0.5-1.5:
- about 0.5-1.5, about 9.5-10.5:
- about 0.75-1.25:
- about 0.75-1.25, about 9.5-10.5:
- about 0.8-1.2:
- about 0.8-1.2, about 9.75-10.5:
- about 0.9-1.1:
- about 0.9-1.1, about 9-12:
- about 0.15-2.5:
- about 0.15-2.5, about 9-12:
- about 0.2-2.5:
- about 0.2-2.5, about 9-12:
- about 0.25-2.5:
- about 0.25-2.5, about 9-12:
- about 0.35-2.5:
- about 0.35-2.5, about 9-12:
- about 0.45-2.5:
- about 0.45-2.5, about 9-12:
- about 0.5-2.5:
- about 0.5-2.5, about 9-12:
- about 0.16-2:
- about 0.16-2, about 9-12:
- about 0.2-2:
- about 0.2-2, about 9-12:
- about 0.25-2:
- about 0.25-2, about 9-12:
- about 0.25-2:
- about 0.25-2, about 9-12:
- about 0.45-2:
- about 0.45-2, about 9-12:
- about 0.5-2:
- about 0.5-2, about 9-12:
- about 0.16-1.5:
- about 0.16-1.5, about 9-12:
- about 0.2-1.5:
- about 0.2-1.5, about 9-12:
- about 0.25-1.5:
- about 0.25-1.5, about 9-12:
- about 0.7-1.5:
- about 0.35-1.5, about 9-12:
- about 0.45-1.5:
- about 0.45-1.5, about 9-12:
- about 0.5-1.5:
- about 0.5-1.5, about 9-12:
- about 0.16-1:
- about 0.16-1, about 9-12:
- about 0.2-1:
- about 0.2-1, about 9-12:
- about 0.25-1:
- about 0.25-1, about 9-12:
- about 0.35-1:
- about 0.35-1, about 9-12:
- about 0.45-1:
- about 0.45-1, about 9-12:
- about 0.5-1:
- about 0.5-1, about 10:
- about 0.5-2.5:
- about 0.5-2.5, about 10:
- about 0.1-1.5:
- about 0.1-1.5, about 9-12:
- about 0.25-0.75:
- about 0.25-0.75, about 9.5-10.5:
- about 0.35-0.7:
- about 0.35-0.7, about 9.5-10.5:
- about 0.4-0.6:
- about 0.4-0.6, and about 9.75-10.5:
- about 0.45-0.6:
- about 0.45-0.6;
- and wherein said triterpene-responsive condition, disease, or disorder is cancer.
12) A method of treating brain tumor comprising administering to a subject in need thereof a therapeutically effective amount of a triterpene-based composition comprising oleanolic acid (or salt thereof), ursolic acid (or salt thereof), and betulinic acid (or salt thereof), wherein the molar ratio of OA to UA to BA is in the range of about 10:
- about 1:
- about 1, or about 9-12:
- about 0.2-2.5:
- about 0.2-2.5.
Dependencies are inferred from the claim text.