Pharmaceutical combination for use in age-related and/or degenerative diseases

A method for the prevention, stabilization, and/or reduction of age-related complaints and/or degenerative complaints, the method comprising:

• administering to a subject in need thereof a pharmaceutical combination comprising:
• a biguanide, or an N-oxide, a hydrate, a pharmaceutically acceptable salt or solvate thereof;
• and
• an acetylcholinesterase inhibitor, or an N-oxide, a hydrate, a pharmaceutically acceptable salt or solvate thereof,
• wherein the age-related complaints and/or degenerative complaints are selected from the group consisting of muscular weakness, decreased muscular strength, neuro-muscular degeneration, impaired mobility, impaired immune response, metabolic imbalance, and general weakness.

A method for improving a measure of life span and/or health span, the method comprising:

• administering to a subject a pharmaceutical combination comprising:
• a biguanide, or an N-oxide, a hydrate, a pharmaceutically acceptable salt or solvate thereof;
• and
• an acetylcholinesterase inhibitor, or an N-oxide, a hydrate, a pharmaceutically acceptable salt or solvate thereof,
• wherein:
• the improved measure of life span and/or health span is selected from the group consisting of the mitigation or stabilization of age-related complaints, the mitigation or stabilization of degenerative dysfunctioning, and degenerative complaints, relative to the condition of the subject before administration of the pharmaceutical combination or relative to a control population;
• and
• the age-related complaints and/or degenerative complaints are selected from the group consisting of muscular weakness, decreased muscular strength, neuro-muscular degeneration, impaired mobility, impaired immune response, metabolic imbalance, and general weakness.