Edible, single-extraction curcuma extracts
AssigneeCalifornia Northstate College of Pharmacy, LLC
Inventorslndiran Pather, Tibebe Zewdie Woldemariam
Life of this patent
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Abstract
Methods of making safe extracts of Curcuma are provided. The processes provided include methods that use an extraction solvent that is at least substantially non-toxic and useful also as a pharmaceutically acceptable carrier in liquid dosage forms. The processes can produce a significantly higher yield from a single extraction than the state-of-the-art processes. For example, liquid dosage forms can be produced directly from the extraction process without requiring removal of the extraction solvent, reducing complexity and cost of processing over the state-of-the-art. Methods of making microemulsions and nanoemulsions are also provided to enhance the bioavailability and stability of the extracts.
Claims36
A method of preparing a formulation acceptable for oral administration having a pharmaceutically acceptable liquid extract of Curcuma, the method comprising:
- macerating at least a portion of a Curcuma root for an effective time in an at least substantially non-toxic extraction solvent that includes a component selected from the group consisting of sesame oil, liquid paraffin, glycerin, squalene, cotton seed oil, liquid-grade polyethylene glycol, isopropyl myristate, polysorbate 80, a sorbitan alkanoate, an ethoxylated sorbitan alkanoate, and combinations thereof;
- separating the extraction solvent from the macerated Curcuma root to create a liquid extract of Curcuma, the extract including curcumin;
- and,
- incorporating the liquid extract directly into the formulation without removal of the extraction solvent, the carrier having the acute oral toxicity with the LD50 of at least 49,700 mg/kg which is at least substantially less toxic than ethanol.
A method of preparing a formulation acceptable for oral administration having a pharmaceutically acceptable emulsion of a liquid extract of Curcuma, the method comprising:
- macerating at least a portion of a Curcuma root for an effective time in an at least substantially non-toxic extraction solvent that includes a component selected from the group consisting of sesame oil, liquid paraffin, glycerin, squalene, cotton seed oil, liquid-grade polyethylene glycol, isopropyl myristate, polysorbate 80, a sorbitan alkanoate, an ethoxylated sorbitan alkanoate, and combinations thereof;
- separating the extraction solvent from the portion of the macerated Curcuma root to create a liquid extract of Curcuma, the extract including curcumin;
- emulsifying the liquid extract;
- and,
- incorporating the emulsified liquid extract directly into the formulation for oral administration without removal of the extraction solvent, the carrier having the acute oral toxicity with the LD50 of at least 49,700 mg/kg which is at least substantially less toxic than ethanol.
Dependencies are inferred from the claim text.