Liposomal compositions and uses of same
AssigneeTechnion Research & Development Foundation Limited
InventorsMarcelle MACHLUF, Tomer BRONSHTEIN
Life of this patent
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Abstract
Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.
Claims22
A composition-of matter comprising a spherical particle composed of a whole cell membrane fraction, wherein the spherical particle exhibits native membrane symmetry and expression of native markers, said spherical particle encapsulating or conjugated to a pharmaceutical agent being exogenous to the cell from which said whole cell membrane is obtained.
A composition-of matter comprising a spherical particle composed of a whole cell membrane fraction of a cell, wherein said spherical particle exhibits native membrane symmetry and expression of native markers.
A method of producing spherical particles exhibiting native membrane symmetry and expression of native markers, the method comprising,
- (a) subjecting cells to hypotonic conditions, so as to obtain ruptured cell membranes and/or ghosts;
- and
- (b) homogenizing said ruptured cell membranes and/or ghosts to thereby produce spherical particles, wherein the method is devoid of membrane solubilization in the presence of a detergent,
- thereby producing the spherical particles exhibiting native membrane symmetry and expression of native markers.
Dependencies are inferred from the claim text.