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US 2021/0267890 A1Published application
Mucoadhesive lipidic delivery system
AssigneeUniversity of Saskatchewan
InventorsEllen K. Wasan, Kishor M. Wasan, Volker Gerdts, Stacy Strom
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Abstract
Methods and compositions for enhancing an immune response, such as a mucosal immune response, to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites.
Claims21
A mucoadhesive lipidic carrier system comprising:
- a triple adjuvant composition that comprises a host defense peptide, an immunostimulatory sequence and a polyanionic polymer, formulated with a mucoadhesive lipidic carrier, wherein said mucoadhesive lipidic carrier system is capable of enhancing an immune response to a selected antigen.
A cationic mucoadhesive liposome carrier system, wherein the system comprises (a) DDAB and DOPE;
- DDAB, EPC and DOPE;
- SA and Chol;
- EPC and Chol;
- or SA/EPC and Chol;
- (b) IDR-1002 (SEQ ID NO:19);
- (c) poly(I:C);
- (d) poly(di-4-oxyphenylproprionate)phosphazene (PCEP);
- and (e) an antigen from a pathogen that invades mucosal tissue.
5 more elements
Dependencies are inferred from the claim text.