Systems and methods for delivery of a therapeutic agent
AssigneesTearclear Corp., University of Florida Research Foundation, Inc.
InventorsHoward L. GOLUB, Anuj CHAUHAN, Michael WILLIAMS
Life of this patent
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Abstract
The present disclosure relates to nozzles for removing a preservative from a fluid comprising a therapeutic agent to an eye. More particularly, the nozzles disclosed herein may minimize patient exposure to preservative by rapidly and selectively removing a preservative from a solution comprising a therapeutic agent. An example nozzle may comprise a flow diverter which directs a flow path from a fluid inlet to a fluid outlet over a length longer than the distance from the inlet to the outlet. In some cases, the nozzle may comprise a preservative removing agent.
Claims20
A device for removing a preservative from a formulation comprising a therapeutic agent, the device comprising:
- a nozzle comprising:
- a fluid outlet;
- an inlet cap comprising one or more apertures, the one or more apertures comprising a fluid inlet, wherein the inlet cap has a hydraulic permeability less than 10 Darcy;
- and
- a matrix disposed within the nozzle, wherein the matrix comprises absorbed particles of the preservative and wherein the hydraulic permeability of the inlet cap is less than a hydraulic permeability of the matrix.
A nozzle for removing a preservative from a fluid comprising a therapeutic agent to treat an eye, the nozzle comprising:
- a fluid inlet configured to receive fluid from a container;
- a fluid outlet coupled to the inlet, the outlet configured to deliver the fluid comprising the therapeutic agent to the eye;
- a distance extending along an axis from the fluid inlet to the fluid outlet;
- a fluid flow path extending from the fluid inlet to the fluid outlet, a porous material along the flow path to selectively remove the preservative;
- and
- a flow diverter to divert regions of the fluid flow path in a plurality of different directions, a total distance along the fluid flow path through the porous material from the inlet to the outlet greater than the distance from the fluid inlet to the fluid outlet along the axis.
A method of removing preservative from a therapeutic agent, the method comprising:
- receiving a solution comprising the therapeutic agent and a preservative;
- squeezing a compressible bottle comprising a nozzle for removing a preservative from a fluid comprising the therapeutic agent to an eye, wherein the nozzle comprises a fluid inlet, a fluid outlet, and a flow path extending from the fluid inlet to the fluid outlet;
- and
- wherein a flow diverter directs flow of the solution in a plurality of different directions, the flow path greater than the distance from the inlet to the outlet.
Dependencies are inferred from the claim text.