Intraocular drug delivery platform
AssigneesSpyGlass Pharma, Inc., The Regents of the University of Colorado, a body corporate
InventorsGlenn Robert Sussman, Craig Alan Cable, II, Malik Y. Kahook
Life of this patent
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Abstract
An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.
Claims21
An intraocular drug delivery platform (13) for use with an intraocular lens assembly (12), comprising:
- a ring (14) having an anterior surface (14A) and a posterior surface (14P) and a central aperture (15);
- a drug eluting mass or other solid drug mass (17) comprising a therapeutic agent, configured to be disposed on the anterior surface (14A), and releasable attachment means (16) for releasably securing the mass to the anterior surface (14A);
- and
- a skirt (19) extending posteriorly from the posterior surface (14P), said skirt circumscribing, partially or fully, the aperture (15);
- wherein
- the skirt (19) is configured to retain the intraocular lens assembly (12), with an inner diameter larger than both an intraocular lens (20) of the intraocular lens assembly and the aperture (15).
An intraocular drug delivery platform (13) for use with an intraocular lens assembly (12), comprising:
- a ring (14) having an anterior surface (14A) and a posterior surface (14P) and a central aperture (15);
- a drug eluting mass or other solid drug mass (17) comprising a therapeutic agent, configured to be disposed on the anterior surface (14A), and releasable attachment means (16) for releasably securing the mass to the anterior surface (14A);
- and
- a skirt (19) extending posteriorly from the posterior surface (14P), said skirt circumscribing, partially or fully, the aperture (15);
- wherein
- the skirt (19) is configured to extend around the intraocular lens to prevent the platform from migrating to the visual axis, with an inner diameter larger than both an intraocular lens (20) of the intraocular lens assembly and the aperture (15).
An intraocular drug delivery platform (13) for use with an intraocular lens assembly (12), comprising:
- a ring (14) having an anterior surface (14A) and a posterior surface (14P) and a central aperture (15);
- a skirt (19) extending posteriorly from the posterior surface (14P), said skirt circumscribing, partially or fully, the aperture (15);
- wherein
- the skirt (19) is configured to retain the intraocular lens assembly (12), with an inner diameter larger than both an intraocular lens (20) of the intraocular lens assembly and the aperture (15);
- and wherein
- the ring (14) or the skirt (19) or both the ring and the skirt comprise a drug eluting mass or other solid drug mass comprising a therapeutic agent.
A method for intraocular delivery of therapeutic agent into an eye of a patient, said method comprising the steps of:
- inserting an intraocular drug delivery platform (13) into the capsular bag or ciliary sulcus of the patient, said intraocular drug delivery platform (13) comprising:
- a ring (14) having an anterior surface (14A) and a posterior surface (14P) and a central aperture (15);
- a releasable attachment means (16) for releasably securing a first drug eluting mass and a second drug eluting mass to the anterior surface (14A);
- wherein the first drug eluting mass is fixed to the releasable attachment means before or after the drug delivery platform is implanted in the eye of the patient;
- with the intraocular drug delivery platform (13) disposed within the eye of the patient, inserting one of the first drug eluting mass (17) or the second drug eluting mass into the eye of the patient and securing the first drug eluting mass (17) or said second drug eluting mass to the ring (14) with the releasable attachment means (16).
A method for intraocular delivery of therapeutic agent into an eye of a patient, said method comprising the steps of:
- inserting an intraocular drug delivery platform (13) into the capsular bag or ciliary sulcus of the patient, said intraocular drug delivery platform (13) comprising:
- a ring (14) having an anterior surface (14A) and a posterior surface (14P) and a central aperture (15);
- a skirt (19) extending posteriorly from the posterior surface (14P), said skirt circumscribing, partially or fully, the aperture (15);
- wherein
- the skirt (19) is configured to retain the intraocular lens assembly (12), with an inner diameter larger than both an intraocular lens (20) of the intraocular lens assembly and the aperture (15);
- and
- placing the intraocular drug delivery platform (13) in a position anterior to an intraocular lens (20) disposed within the eye of the patient such that the posterior surface of the ring (14P) is opposed to an anterior surface (20A) of the intraocular lens, such that the intraocular lens is disposed within the skirt (19).
Dependencies are inferred from the claim text.