Electrode assembly including expandable isolation member

An electroporation system comprising:

• a catheter shaft;
• an electrode assembly coupled to the catheter shaft, the electrode assembly comprising:
• an electrode pair comprising a first electrode and a second electrode configured to be selectively energized for delivery of electroporation therapy;
• and
• an expandable isolation member disposed axially between the first electrode and the second electrode, wherein one of the first electrode and the second electrode is positioned proximally of a proximal end of the expandable isolation member and the other of the first electrode and the second electrode is positioned distal to a distal end of the expandable isolation member, the expandable isolation member configurable between a collapsed configuration and an expanded configuration;
• wherein the expandable isolation member comprises a circumferential sealing surface configured for sealing engagement with tissue of a patient such that the expandable isolation member inhibits fluid and electrical communication between the first electrode and the second electrode when engaged with tissue of the patient;
• and
• an electroporation generator coupled in communication with the first electrode and the second electrode and configured to supply an electroporation signal thereto for the delivery of the electroporation therapy to the tissue of the patient.