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US 2021/0267499 A1Published application
System and method for intraoperative detection of cancer margins using conformal filters in a dual polarization configuration
AssigneeChemImage Technologies LLC
InventorsShona STEWART, Serena AUGUSTINE, Jeffrey COHEN, Ryan PRIORE
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Abstract
Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.
Claims44
A system comprising:
- an intraoperative optical diagnostic device configured to detect features of a biological sample comprising:
- an optical separator positioned to receive interacted photons from the biological sample and configured to separate the interacted photons into a first optical path and a second optical path;
- a first conformal filter positioned to receive interacted photons from the first optical path, the first conformal filter having one or more filter stages configured to filter the interacted photons in the first optical path and generate a first filtered component;
- a second conformal filter positioned to receive interacted photons from the second optical path, the second conformal filter having one or more filter stages configured to filter the interacted photons in the second optical path and generate a second filtered component;
- a controller in communication with the first conformal filter and the second conformal filter, the controller being configured to apply one or more voltages to each of the one or more filter stages of the first conformal filter and each of the one or more filter stages of the second conformal filter;
- and
- one or more detectors positioned to receive the first filtered component, the second filtered component or combinations thereof, each of the one or more detectors being configured to detect the first filtered component, the second filtered component, or combinations thereof and generate image data from the first filtered component, the second filtered component, or combinations thereof;
- and
- a processor connected to each of the one or more detectors and the controller, the processor being configured to analyze the image data and generate images related thereto, the processor being further configured to cause the controller to individually apply a voltage to each stage of each of the first conformal filter and the second conformal thereby individually tuning each of the first conformal filter and second conformal filter.
6 more elements
A method for detecting one or more features of a biological tissue, the method comprising:
- separating interacted photons comprising photons that have interacted with one or more analytes in a biological sample into a first optical path and a second optical path;
- passing the first optical path through a first conformal filter comprising one or more filter stages and generating a first filtered component;
- passing the second optical path through a second conformal filter comprising one or more filter stages and generating a second filtered component;
- applying one or more voltages to the one or more stages of the first conformal filter and to the one or more stages of the second conformal filter;
- detecting the first filtered component and the second filtered component and generating one or more test data sets;
- and
- analyzing the one or more test data sets with a computer processor to detect the one or more features of the biological tissue.
4 more elements
Dependencies are inferred from the claim text.