Mass correction
AssigneeMicromass UK Limited
InventorMartin Raymond Green
Life of this patent
Estimating the term…
Abstract
Disclosed is a method of mass spectrometry comprising the steps of: providing a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components as a function of retention time; chromatographically separating a sample, said sample containing at least some of said matrix components and one or more analyte components; analysing said sample at a plurality of retention times to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components as a function of retention time; and calculating one or more error values as a function of retention time based on a comparison between said sample data and said matrix data.
Claims18
A method of mass spectrometry comprising the steps of:
- providing a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components as a function of retention time;
- chromatographically separating a sample, said sample containing at least some of said matrix components and one or more analyte components;
- analysing said sample at a plurality of retention times to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components as a function of retention time;
- calculating one or more error values as a function of retention time based on a comparison between said sample data and said matrix data.
A mass spectrometer comprising:
- a control system arranged and adapted:
- to provide a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components as a function of retention time;
- wherein said mass spectrometer further comprises:
- a chromatography system arranged and adapted to chromatographically separate a sample, said sample containing at least some of said matrix components and one or more analyte components, and to analyse said sample at one or more retention times to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components as a function of retention time;
- wherein said control system is further arranged and adapted:
- to calculate one or more error values as a function of retention time based on a comparison between said sample data and said matrix data.
A method of mass spectrometry comprising the steps of:
- providing a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components;
- imaging a sample at a plurality of spatial locations, said sample containing at least some of said matrix components and one or more analyte components;
- analysing said sample at said plurality of spatial locations to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components;
- calculating one or more error values based on a comparison between said sample data and said matrix data, wherein each error value is associated with a given spatial location.
A mass spectrometer comprising:
- a control system arranged and adapted:
- to provide a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components;
- wherein said mass spectrometer further comprises:
- an ion imaging system arranged and adapted:
- to image a sample at a plurality of spatial locations, said sample containing at least some of said matrix components and one or more analyte components;
- and
- to analyse said sample at one or more spatial locations to obtain sample data, said sample data comprising one or more physico-chemical properties of one or more sample components;
- wherein said control system is further arranged and adapted:
- to calculate one or more error values based on a comparison between said sample data and said matrix data, wherein each error value is associated with a given spatial location.
Dependencies are inferred from the claim text.