Systems and methods to facilitate determination of interaction between medications and the brain using a brain measure and a brain model

A computer-implemented method, comprising:

• using a processor, operatively coupled to a memory, to execute computer executable components to perform the following acts:
• using the processor to train parameterization of a generative model by receiving sequences of medical records described by a disease progression model and translates the sequences of medical records to an illustrative sequence of corresponding images, wherein the training is performed by:
• using the processor to predict a first future patient state and first medical record from a first sequence of medical records;
• using the processor to predict a second future patient state and second medical image from a second sequence of medical images;
• and
• using the processor to generate a pathophysiological simulation of a third future patient state using a third sequence of medical images given a first set of parameters wherein a first parameter reflects a population of patients that have presented a first type of medical record.

A computer program product comprising a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a processor to cause the processor to:

• train, using the processor, parameterization of a generative model by receiving sequences of medical records described by a disease progression model and translates the sequences of medical records to an illustrative sequence of corresponding images, wherein the training is performed by:
• predicting, using the processor, a first future patient state and first medical record from a first sequence of medical records;
• predicting, using the processor, a second future patient state and second medical image from a second sequence of medical images;
• and
• generating, using the processor, a pathophysiological simulation of a third future patient state using a third sequence of medical images given a first set of parameters wherein a first parameter reflects a population of patients that have presented a first type of medical record.