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US 2021/0263122 A1Published application
Ratiometric pulsed cest imaging
AssigneeBracco Imaging S.P.A.
InventorsSilvio AIME, Dario Livio LONGO, Sonia COLOMBO SERRA, Lorena CONSOLINO, Francesca ARENA
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Abstract
The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer-based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
Claims23
A Chemical Exchange-dependent Saturation Transfer-Magnetic Resonance (CEST-MR) procedure that comprises:
- i) applying a train saturation scheme of Radio Frequency (RF) irradiation pulses with different flip angles to a single mobile-proton frequency of an exogenous CEST agent in a sample, for inducing a Chemical Exchange Rotation Transfer (CERT)-based Saturation Transfer effect (ST effect);
- and
- ii) detecting CERT-based CEST-signals from said sample.
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Dependencies are inferred from the claim text.