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US 2021/0262017 A1Published application
Sensors for nucleic acid biomarkers
AssigneeMemorial Sloan Kettering Cancer Center
InventorsJackson HARVEY, Daniel HELLER, Prakrit JENA
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Abstract
Described herein are novel devices and methods for the optical detection of oligonucleotide binding events for diagnostic, point-of-care, drug screening, and theranostic applications, for example, a robust and customizable system to detect specific DNA and RNA oligonucleotides using a carbon nanotube optical signal.
Claims28
A single-walled carbon nanotube (SWCNT) sensor, comprising:
- a SWCNT;
- a polymer associated with the SWCNT, wherein the polymer comprises DNA, RNA, a locked nucleic acid (LNA), glycol nucleic acid (GNA), or threose nucleic acid (TNA), and wherein the polymer comprises two or more domains.
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