Method of personalized treatment for cardiomyopathy and heart failure and other related diseases by measuring renin activity, pro-renin, pro-renin receptor levels in blood

A method of monitoring effectiveness of a treatment in a patient with a heart condition, wherein the treatment is currently being administered to said patient, comprising the steps of:

• a. determining plasma renin activity of the patient by:
• i. obtaining a blood sample from the patient;
• ii. measuring plasma renin activity, and/or measuring pro-renin activity and/or measuring (pro)-renin receptor (PRR) levels wherein plasma renin activity comprises plasma renin activity (PRA), plasma renin activity concentration (PRAC), active renin concentration (ARC), and/or active plasma renin concentration (APRC);
• and
• iii. determining a status of the heart condition in said patient or risk of death of said patient based on measured PRA, PRAC, ARC, and/or APRC, and/or measured pro-renin activity and/or measured PRR levels;
• b. determining changes in plasma renin activity compared to a baseline level;
• wherein if the patient has an increase of plasma renin activity by more than 5% compared to the baseline level, a different treatment administered to the patient;
• wherein if the patient has a decrease of plasma renin activity of more than 5% compared to the baseline level, the patient maintains the current treatment.