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US 2021/0261901 A1Published application
Cell engineering platform
AssigneeAvectas Limited
InventorMichael Maguire
Life of this patent
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Abstract
The current subject matter provides a cell engineering platform of a diagnostic and clinical use scale for vector-free and/or viral delivery of payload/cargo compounds and compositions into non-adherent cells. The platform achieves delivery to a large number of cells quickly in a closed system. Related apparatus, systems, techniques, articles and compositions are also described.
Claims74
A method comprising:
- filling a chamber of a cell engineering platform with a mixture of cells and a first medium;
- and
- discharging the first medium from the chamber through a filter, leaving the cells deposited on the filter,
- wherein the cell engineering platform includes:
- a chamber;
- a lid disposed at a first end of the chamber;
- a base disposed at a second end of the chamber;
- and
- a filter holder disposed within the chamber.
6 more elements
A system comprising:
- a housing configured to receive a filter plate comprising a well;
- a differential pressure applicator configured to apply a differential pressure to the well;
- a delivery solution applicator configured to deliver atomized delivery solution to the well;
- a stop solution applicator configured to deliver a stop solution to the well;
- and
- a culture medium applicator configured to deliver a culture medium to the well.
3 more elements
A system comprising:
- a chamber;
- a lid disposed at a first end of the chamber;
- a base disposed at a second end of the chamber;
- and
- a filter holder disposed within the chamber.
2 more elements
(canceled)
Dependencies are inferred from the claim text.