Anti-bcma car antibodies, conjugates, and methods of use
Assigneebluebird bio, Inc.
InventorsKevin FRIEDMAN, Molly Reed PERKINS
Life of this patent
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Abstract
The invention provides improved methods for detecting anti-BCMA CAR expression on T cells.
Claims64
An antibody or antigen binding fragment thereof comprising one or more CDRs that bind an anti-BCMA chimeric antigen receptor (CAR).
An antibody or antigen binding fragment thereof comprising a variable light chain comprising CDRL1-CDRL3 sequences set forth in SEQ ID NOs:
- 1-3, and a variable heavy chain comprising CDRH1-CDRH3 sequences set forth in SEQ ID NOs:
- 4-6.
An antibody or antigen binding fragment thereof comprising a variable light chain comprising CDRL1-CDRL3 sequences set forth in SEQ ID NOs:
- 9-11, and a variable heavy chain comprising CDRH1-CDRH3 sequences set forth in SEQ ID NOs:
- 12-14.
An antibody or antigen binding fragment thereof comprising a variable light chain comprising CDRL1-CDRL3 sequences set forth in SEQ ID NOs:
- 17-19, and a variable heavy chain comprising CDRH1-CDRH3 sequences set forth in SEQ ID NOs:
- 20-22.
Dependencies are inferred from the claim text.