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US 2021/0261679 A1Published application
Anti-transferrin receptor antibodies and uses thereof
AssigneeAvidity Biosciences, Inc.
InventorsBeatrice Diana DARIMONT, Venkata Ramana DOPPALAPUDI, Rachel JOHNS
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Abstract
Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.
Claims17
A method of treating a muscle atrophy or myotonic dystrophy in a subject in need thereof, comprising:
- administering to the subject an anti-transferrin receptor antibody conjugate comprising i) anti-transferrin receptor antibody comprising a variable heavy chain (VH) region and a variable light chain (VL) region, wherein the VH region comprises HCDR1 sequence comprising SEQ ID NO:
- 1;
- HCDR2 sequence EINPIX1GRSNYAX2KFQG, wherein X1 is selected from N or Q and X2 is selected from Q or E;
- and HCDR3 sequence comprising SEQ ID NO:
- 3, and ii) a payload, wherein the payload mediates RNA interference against an atrogene, thereby treating muscle atrophy or myotonic dystrophy in the subject.
2 more elements
Dependencies are inferred from the claim text.