Mutated tau protein fragment and use thereof
AssigneeAdel Inc.
InventorsSeung-Yong YOON, Na-Young Kim, Dong-Hou Kim
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Abstract
A mutated tau protein fragment and a use thereof are disclosed. The mutated tau protein fragment consists 12 amino acid residues and thus can easily be prepared. In addition, when the mutated tau protein fragment is injected into an individual as an antigen, a neutralizing antibody against the mutated tau protein is generated. Moreover, the mutated tau protein fragment reduces the aggregation of abnormal tau proteins. Accordingly, the mutated tau protein fragment can be effectively used for the prevention or treatment of degenerative neurological diseases.
Claims14
An antibody capable of specifically binding to a modified tau protein fragment consisting of the following sequence of 12 consecutive amino acid residues:
- Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-Ser-Asn (SEQ ID NO:
- 1) where lysine at position 6 of SEQ ID NO:
- 1 is acetylated,
- or an antigen-binding fragment thereof.
Dependencies are inferred from the claim text.