Back to results
US 2021/0261503 A1Published application
Preparation of secondary amines with electrophilic n-linchpin reagents
AssigneeWilliam Marsh Rice University
InventorsPadmanabha Venkatesh KATTAMURI, Laszlo KURTI
Life of this patent
Estimating the term…
Abstract
In one aspect, the present disclosure provides methods of preparing a secondary amine. In some embodiments, the secondary amine comprises two different groups or two identifical groups. Also provided herein are compositions for use in the preparation of the secondary amine.
Claims22
A compound of the formula:
- wherein:
- X1 and X2 are each independently C, S, or S(O);
- R1 and R2 are each independently amino, hydroxy, or alkoxy(C≤12), cycloalkoxy(C≤12), alkenyloxy(C≤12), alkynyloxy(C≤12), aryloxy(C≤12), aralkoxy(C≤12), heteroaryloxy(C≤12), heterocycloalkoxy(C≤12), alkylamino(C≤12), dialkylamino(C≤12), cycloalkylamino(C≤12), dicycloalkylamino(C≤12), alkenylamino(C≤12), dialkenylamino(C≤12), alkynylamino(C≤12), dialkynylamino(C≤12), arylamino(C≤12), diarylamino(C≤12), aralkylamino(C≤12), diaralkylamino(C≤12), heteroarylamino(C≤12), diheteroarylamino(C≤12), heterocycloalkylamino(C≤12), diheterocycloalkyl-amino(C≤12), or a substituted version of any of these groups;
- and
- R3 is a leaving group or alkyl(C≤18), cycloalkyl(C≤18), alkenyl(C≤18), alkynyl(C≤18), aryl(C≤18), aralkyl(C≤18), heteroaryl(C≤18), heterocycloalkyl(C≤18), or a substituted version of any of these groups;
- or a salt thereof.
3 more elements
A compound of the formula:
- wherein:
- X1 and X2 are each independently C, S, or S(O);
- and
- R1 and R2 are each independently amino, hydroxy, or alkoxy(C≤12), cycloalkoxy(C≤12), alkenyloxy(C≤12), alkynyloxy(C≤12), aryloxy(C≤12), aralkoxy(C≤12), heteroaryloxy(C≤12), heterocycloalkoxy(C≤12), alkylamino(C≤12), dialkylamino(C≤12), cycloalkylamino(C≤12), dicycloalkylamino(C≤12), alkenylamino(C≤12), dialkenylamino(C≤12), alkynylamino(C≤12), dialkynylamino(C≤12), arylamino(C≤12), diarylamino(C≤12), aralkylamino(C≤12), diaralkylamino(C≤12), heteroarylamino(C≤12), diheteroarylamino(C≤12), heterocycloalkylamino(C≤12), diheterocycloalkyl-amino(C≤12), or a substituted version of any of these groups;
- or a salt thereof.
2 more elements
A compound of the formula:
- wherein:
- X1 and X2 are each independently C, S, or S(O);
- and
- R1 and R2 are each independently amino, hydroxy, or alkoxy(C≤12), cycloalkoxy(C≤12), alkenyloxy(C≤12), alkynyloxy(C≤12), aryloxy(C≤12), aralkoxy(C≤12), heteroaryloxy(C≤12), heterocycloalkoxy(C≤12), alkylamino(C≤12), dialkylamino(C≤12), cycloalkylamino(C≤12), dicycloalkylamino(C≤12), alkenylamino(C≤12), dialkenylamino(C≤12), alkynylamino(C≤12), dialkynylamino(C≤12), arylamino(C≤12), diarylamino(C≤12), aralkylamino(C≤12), diaralkylamino(C≤12), heteroarylamino(C≤12), diheteroarylamino(C≤12), heterocycloalkylamino(C≤12), diheterocycloalkyl-amino(C≤12), or a substituted version of any of these groups;
- or a salt thereof.
2 more elements
-17. (canceled)
-31. (canceled)
Dependencies are inferred from the claim text.