Non-invasive Agent Applicator
AssigneeMuPharma Pty Ltd
InventorsHarry Unger, Mark Unger, Sean Michael Langelier
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Abstract
There is disclosed systems and methods for non-invasive delivery of an agent to biological tissues. Delivery of the agent to the tissues can be by one or more modalities. In some embodiments the systems and methods use agent carrier body including a tissue contacting surface for non-invasively engaging tissues under treatment. The tissue contacting surface can be at least partly defined by a plurality of protrusions that are in fluid communication with one or more reservoirs forming part of the agent carrier body. The protrusions may extend outward from an inside of a void and terminate at said tissue contacting surface.
Claims20
A method of inducing an immune response in a subject, including the steps of:
- applying ultrasound to an agent within an agent carrier body, agent carrier or agent applicator, wherein ultrasound is the transportation stimulus;
- the agent carrier body comprising a tissue contacting surface for engaging a tissue;
- and
- configuring operational parameters of the agent applicator to enhance or enable delivery of said agent to one or more selected layers of the tissue;
- wherein:
- the agent carrier body does not penetrate any layer of the tissue surface,
- delivery of the agent induces at least a mucosal immune response in the subject, and
- the agent is delivered to or beyond any one or more of the tissues and tissue layers selected from the group consisting of:
- mucous membrane;
- mucosa;
- epithelial or sub-epithelial layer of a mucous membrane;
- sub-mucosa;
- and
- mucous membrane vasculature.
Dependencies are inferred from the claim text.